{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McDaniel JH"],"funding":["United States Department of Commerce | National Institute of Standards and Technology (NIST)","NIA NIH HHS","U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)","NHGRI NIH HHS","National Science Foundation (NSF)","NCI NIH HHS","U.S. Department of Health & Human Services | National Institutes of Health (NIH)","NIGMS NIH HHS","NIH HHS"],"pagination":["1195"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12267650"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["The Genome in a Bottle Consortium (GIAB), hosted by the National Institute of Standards and Technology (NIST), is developing new matched tumor-normal samples, the first explicitly consented for public dissemination of genomic data and cell lines. Here, we describe a comprehensive genomic dataset from the first individual, HG008, including DNA from an adherent, epithelial-like pancreatic ductal adenocarcinoma (PDAC) tumor cell line and matched normal cells from duodenal and pancreatic tissues. Data for the tumor-normal matched samples comes from seventeen distinct state-of-the-art whole genome measurement technologies, including high depth short and long-read bulk whole genome sequencing (WGS), single cell WGS, Hi-C, and karyotyping. These data will be used by the GIAB Consortium to develop"],"journal":["Scientific data"],"pubmed_title":["Development and extensive sequencing of a broadly-consented Genome in a Bottle matched tumor-normal pair."],"pmcid":["PMC12267650"],"funding_grant_id":["R01 CA266279","U01 CA253405","60NANB20D166","R35GM133747","OT2OD034190","OT2 OD034190","R35 GM133747","R01 HG011274","U24 HG011853","R01HG011274","U24HG011853","S10 OD028587","P01 CA272295","U54 AG089334","1936791","U01CA253405","1919691"],"pubmed_authors":["Shelton J","Akeson S","Paten B","Ahmad T","Lambert C","Mehta H","Steinsnyder Z","Krieger G","Husar G","Remington J","Proszynski J","Cole KD","Sudkamp M","Hirschberg JW","Catreux S","Park J","Iremadze N","Jain M","Bhakta MS","Patel V","Violich I","Wagner J","Sikkink K","Rojas A","Scheffler K","Lajoie BR","Hannah LC","Kennedy K","Wenger AM","Eacker S","He Z","Narzisi G","Rosen GL","Baybayan P","Levy S","McLaughlin IJ","Truong S","He HJ","Sedlazeck FJ","McDaniel JH","Sanborn JZ","Yu HC","Jhangiani SN","Bryant A","McNulty B","Salas-Gonzalez I","Lipson D","Thibaud-Nissen F","Wiseman K","Vernich M","Wescott M","Cross E","Munding EM","Behera S","Hastie AR","Keskus AG","Paulin LF","Soifer I","Doddapaneni H","Trow J","Gross S","Miga KH","Muzny DM","Benjamin H","Mason CE","Olson ND","Reeves C","Kolmogorov M","Gingras MC","Kingan SB","Gardner J","Gooden AA","Kingsley C","Weigman V","Sayyari E","Brundu F","Kim Y","McCoy R","Liss AS","Zook JM","Ryon K","Xiao C","Schmitt A","Adamson A","Wood M"],"additional_accession":[]},"is_claimable":false,"name":"Development and extensive sequencing of a broadly-consented Genome in a Bottle matched tumor-normal pair.","description":"The Genome in a Bottle Consortium (GIAB), hosted by the National Institute of Standards and Technology (NIST), is developing new matched tumor-normal samples, the first explicitly consented for public dissemination of genomic data and cell lines. Here, we describe a comprehensive genomic dataset from the first individual, HG008, including DNA from an adherent, epithelial-like pancreatic ductal adenocarcinoma (PDAC) tumor cell line and matched normal cells from duodenal and pancreatic tissues. Data for the tumor-normal matched samples comes from seventeen distinct state-of-the-art whole genome measurement technologies, including high depth short and long-read bulk whole genome sequencing (WGS), single cell WGS, Hi-C, and karyotyping. These data will be used by the GIAB Consortium to develop","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-05-01T18:37:00.508Z","creation":"2026-04-07T17:09:00.448Z"},"accession":"S-EPMC12267650","cross_references":{"pubmed":["40670386"],"doi":["10.1038/s41597-025-05438-2"]}}