biostudies-literatureUnknown5(3)Mitra AAnti-N-methyl-ᴅ-aspartate (anti-NMDA) receptor encephalitis is a well-known autoimmune encephalitis caused by antibodies against the GluN1 subunit of the anti-NMDA receptor (anti-NMDAR). Stroke, characterized by abrupt focal neurological deficits due to ischemic or hemorrhagic vascular insults, is rarely preceded by anti-NMDAR encephalitis. Here, we described a case of a 69-year-old female without any prior comorbidities who presented with acute stroke and left hemiparesis with a history of recent onset of neuropsychiatric symptoms. Her cerebrospinal fluid was positive for anti-NMDAR antibody, and significant improvement was noticed after the initiation of immunotherapy. In this patient, stroke occurred following anti-NMDAR encephalitis; however, the pathophysiological link between the twoEncephalitis (Seoul, Korea)71-76https://www.ebi.ac.uk/biostudies/studies/S-EPMC12268045biostudies-literatureAnti-N-methyl-ᴅ-aspartate receptor encephalitis preceding stroke: report of an unusual case with literature review.PMC12268045Srivastava NKMishra VNPathak AVivek AMitra AfalseAnti-N-methyl-ᴅ-aspartate receptor encephalitis preceding stroke: report of an unusual case with literature review.Anti-N-methyl-ᴅ-aspartate (anti-NMDA) receptor encephalitis is a well-known autoimmune encephalitis caused by antibodies against the GluN1 subunit of the anti-NMDA receptor (anti-NMDAR). Stroke, characterized by abrupt focal neurological deficits due to ischemic or hemorrhagic vascular insults, is rarely preceded by anti-NMDAR encephalitis. Here, we described a case of a 69-year-old female without any prior comorbidities who presented with acute stroke and left hemiparesis with a history of recent onset of neuropsychiatric symptoms. Her cerebrospinal fluid was positive for anti-NMDAR antibody, and significant improvement was noticed after the initiation of immunotherapy. In this patient, stroke occurred following anti-NMDAR encephalitis; however, the pathophysiological link between the two2025-01-01T00:00:00Z2025 Jul2026-03-16T00:20:01.017Z2025-08-14T03:05:16.332ZS-EPMC122680454063530910.47936/encephalitis.2025.00017