biostudies-literatureKing-Robson JThe Wolfson FoundationBrain Research UKWolfson FoundationFrontotemporal Dementia Research Studentship in Memory of David BlechnerMedical Research Council Dementias Platform UKRoyal National Institute for Deaf PeopleGuarantors of Brain Entry Clinical Fellowship and a Medical Research Council Clinical Research Training FellowshipInsight 46 by the Alzheimer’s AssociationAlzheimer’s SocietyUK Dementia Research InstituteNational Institute for Health Research (NIHR)Brain Research TrustSelfridges Group FoundationWeston Brain InstituteBritish Heart FoundationAlzheimer’s Research UK Clinical Research Training FellowshipNational Institute for Health and Care Research University College London Hospitals Biomedical Research CentreNational Institute for Health Research for DIADEMNational Institute for Health Research University College London Hospitals Biomedical Research CentreAlzheimer’s AssociationThe Medical Research CouncilMedical Research CouncilNIHR University College London Hospitals Biomedical Research CentreUK Dementia Research Institute and Alzheimer’s AssociationAlzheimer's SocietyNational Brain AppealUCL Centre of Research ExcellenceAlzheimer’s Research UKDRI LtdAlzheimer’s Research UK Blood Biomarker Challenge for the ADAPT studyfcaf264https://www.ebi.ac.uk/biostudies/studies/S-EPMC12268499biostudies-literatureUnknown7(4)Sleep and circadian disturbances are associated with increased dementia risk. The mechanism remains poorly understood. We aimed to examine the relationship between night/shift working at age 31 and biomarkers of late-life brain health and to estimate the extent to which these relationships are mediated by unhealthy lifestyle behaviours. A prospective longitudinal cohort study, Insight 46, recruited participants from the Medical Research Council National Survey of Health and Development (NSHD) 1946 British Birth cohort. All born in the same week in 1946, participants were assessed at age 70 with multi-modal structural and molecular brain imaging and fluid biomarkers, from which whole-brain and hippocampal volumes, white matter hyper-intensity volume (WMHV), ¹⁸F-florbetapir amyloiBrain communicationsAssociations between night/shift working and late-life brain health.PMC12268499ARUK-PG2014-1946ARUK-CRTF2023B-001CSUB19166MC-UU-12019/122/3/18G105_WARRENARUK-PG2017-1946MC-UU-12019/3PR/ylr/18575AS-DRL-23-005UCC14191RE/24/130013ARUK-BBC2023-002SG-666374-UK BIRTH COHORTNIHR204280James SNSchott JMBarnes JWarren JDSudre CHWilliams DMRichards MKeuss SELu KKeshavan AGroves JCoath WKing-Robson JNicholas JMCash DMfalseAssociations between night/shift working and late-life brain health.Sleep and circadian disturbances are associated with increased dementia risk. The mechanism remains poorly understood. We aimed to examine the relationship between night/shift working at age 31 and biomarkers of late-life brain health and to estimate the extent to which these relationships are mediated by unhealthy lifestyle behaviours. A prospective longitudinal cohort study, Insight 46, recruited participants from the Medical Research Council National Survey of Health and Development (NSHD) 1946 British Birth cohort. All born in the same week in 1946, participants were assessed at age 70 with multi-modal structural and molecular brain imaging and fluid biomarkers, from which whole-brain and hippocampal volumes, white matter hyper-intensity volume (WMHV), ¹⁸F-florbetapir amyloi2025-01-01T00:00:00Z20252026-05-10T04:16:53.875Z2025-08-21T09:53:05.763ZS-EPMC122684994067769910.1093/braincomms/fcaf264