{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Perez-Diaz C"],"funding":["Carlos III Health Institute","Ministerio de Ciencia e Innovación","Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España","European Regional Development Fund"],"pagination":["112876"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12270682"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(7)"],"pubmed_abstract":["The aim of this study was to investigate associations between human exposure to persistent organic pollutants and sex hormone levels. The study population (<i>n</i> = 253) was a subsample of GraMo adult cohort, recruited in 2003-2004 in two hospitals from Granada, Spain. Exposure was estimated by analyzing samples of adipose tissue (3 organochlorine pesticides and 3 polychlorinated biphenyls) and serum (4 per- and polyfluoroalkyl substances). Data analyses included robust linear regression and weighted quantile sum regression. In men, PFNA (positively) and PCB-138 (negatively) were associated with testosterone. In premenopausal women, OCPs and PCBs were negatively associated with estradiol and SHBG. PFHxS was inversely related to luteinizing hormone. Additionally, PCB-153 and -180 was posi"],"journal":["iScience"],"pubmed_title":["Associations of internal persistent organic pollutant levels with sex hormones: An analysis by sex and menopausal status in a Spanish cohort."],"pmcid":["PMC12270682"],"funding_grant_id":["PI20/01568","PI16/01812","PI16/01858","RYC-2016-20155","PI18/01573"],"pubmed_authors":["Ramos JJ","Arrebola JP","Martin-Olmedo P","Perez-Diaz C","Olea N","Perez-Carrascosa FM","Echeverria R","Salcedo-Bellido I","Requena P","Barrios-Rodriguez R","Fernandez MF"],"additional_accession":[]},"is_claimable":false,"name":"Associations of internal persistent organic pollutant levels with sex hormones: An analysis by sex and menopausal status in a Spanish cohort.","description":"The aim of this study was to investigate associations between human exposure to persistent organic pollutants and sex hormone levels. The study population (<i>n</i> = 253) was a subsample of GraMo adult cohort, recruited in 2003-2004 in two hospitals from Granada, Spain. Exposure was estimated by analyzing samples of adipose tissue (3 organochlorine pesticides and 3 polychlorinated biphenyls) and serum (4 per- and polyfluoroalkyl substances). Data analyses included robust linear regression and weighted quantile sum regression. In men, PFNA (positively) and PCB-138 (negatively) were associated with testosterone. In premenopausal women, OCPs and PCBs were negatively associated with estradiol and SHBG. PFHxS was inversely related to luteinizing hormone. Additionally, PCB-153 and -180 was posi","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-31T10:20:21.261Z","creation":"2025-08-27T03:06:47.328Z"},"accession":"S-EPMC12270682","cross_references":{"pubmed":["40678528"],"doi":["10.1016/j.isci.2025.112876"]}}