{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Iudin D"],"funding":["European Research Council","Dutch Research Council (NWO)"],"pagination":["4108-4123"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12273623"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(7)"],"pubmed_abstract":["Three-dimensional printing of hydrogels enables the fabrication of complex structures for tissue engineering. Postprinting shrinking via electrostatic interactions offers a promising strategy to better replicate the size and intricacy of native tissues. This study explores hyaluronic acid (HA)-based hydrogels that undergo shrinking upon polycation penetration and complexation focusing on the influence of the HA macromer concentration, molecular weight, cross-linking density, hydrogel initial volume, and polycation properties on shrinking efficiency. To support cell adhesion, RGD peptides were incorporated into the HA network. The polycation concentration strongly affected cell viability: a high concentration of 1 wt % resulted in reduced viability, while 0.1 wt % preserved it with effectiv"],"journal":["Biomacromolecules"],"pubmed_title":["In-Depth Investigation of Electrostatic Interaction-Based Hydrogel Shrinking for Volumetric Printing and Tissue Engineering Applications."],"pmcid":["PMC12273623"],"funding_grant_id":["022.006.003","18673","101115643"],"pubmed_authors":["Iudin D","Levato R","Gerridzen LJJA","Neumann M","Nguyen L","Li W","Casadidio C","van Genderen AM","Hak J","Masereeuw R","Vermonden T","N Bernal P","van Ravensteijn BGP","Schuurmans CCL","Zhang YS","van Steenbergen MJ"],"additional_accession":[]},"is_claimable":false,"name":"In-Depth Investigation of Electrostatic Interaction-Based Hydrogel Shrinking for Volumetric Printing and Tissue Engineering Applications.","description":"Three-dimensional printing of hydrogels enables the fabrication of complex structures for tissue engineering. Postprinting shrinking via electrostatic interactions offers a promising strategy to better replicate the size and intricacy of native tissues. This study explores hyaluronic acid (HA)-based hydrogels that undergo shrinking upon polycation penetration and complexation focusing on the influence of the HA macromer concentration, molecular weight, cross-linking density, hydrogel initial volume, and polycation properties on shrinking efficiency. To support cell adhesion, RGD peptides were incorporated into the HA network. The polycation concentration strongly affected cell viability: a high concentration of 1 wt % resulted in reduced viability, while 0.1 wt % preserved it with effectiv","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-18T14:01:12.538Z","creation":"2025-08-23T03:06:24.652Z"},"accession":"S-EPMC12273623","cross_references":{"pubmed":["40518730"],"doi":["10.1021/acs.biomac.5c00117"]}}