{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu S"],"funding":["NIBIB NIH HHS","NIA NIH HHS","NIDA NIH HHS","NIAID NIH HHS","NIGMS NIH HHS"],"pagination":["5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12276902"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5"],"pubmed_abstract":["Metagenomics has revolutionized our understanding of microbial communities, offering unprecedented insights into their genetic and functional diversity across Earth's diverse ecosystems. Beyond their roles as environmental constituents, microbiomes act as symbionts, profoundly influencing the health and function of their host organisms. Given the inherent complexity of these communities and the diverse environments where they reside, the components of a metagenomics study must be carefully tailored to yield accurate results that are representative of the populations of interest. This Primer article examines the methodological advancements and current practices that have shaped the field, from initial stages of sample collection and DNA extraction to the advanced bioinformatics tools employ"],"journal":["Nature reviews. Methods primers"],"pubmed_title":["Analysis of metagenomic data."],"pmcid":["PMC12276902"],"funding_grant_id":["R35 GM138369","R01 AI173172","R01 AI100947","U01 DA053941","R01 AI125416","U54 AG089334","R21 AI129851","R01 AI151059","R01 GM146462","R21 EB031466","U19 AI174998","R35 GM146980"],"pubmed_authors":["Luan T","Pop M","Crandall KA","Liu S","Della Libera K","Ganda E","Mason C","Zackular JP","Tierney BT","Labaj PP","Blaszczyk D","Andreace F","Gancz AS","Zielinska K","Mutlu O","Davenport ER","Sun F","Van Syoc E","Chikhi R","Rahnavard A","Alser M","Mansouri Ghiasi N","Kosciolek T","Zelikovsky A","Francis D","Rodriguez JS","Vicedomini R","Blekhman R","Jaiswal P","Munteanu V","Koslicki D","Moustafa AM","Muralidharan HS","Sharma NK","Tian S","Mangul S","Ronkowski C","Frolova A","Huntley NE","Labaj W"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of metagenomic data.","description":"Metagenomics has revolutionized our understanding of microbial communities, offering unprecedented insights into their genetic and functional diversity across Earth's diverse ecosystems. Beyond their roles as environmental constituents, microbiomes act as symbionts, profoundly influencing the health and function of their host organisms. Given the inherent complexity of these communities and the diverse environments where they reside, the components of a metagenomics study must be carefully tailored to yield accurate results that are representative of the populations of interest. This Primer article examines the methodological advancements and current practices that have shaped the field, from initial stages of sample collection and DNA extraction to the advanced bioinformatics tools employ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-03-16T07:19:12.108Z","creation":"2025-08-17T03:05:35.136Z"},"accession":"S-EPMC12276902","cross_references":{"pubmed":["40688383"],"doi":["10.1038/s43586-024-00376-6"]}}