{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lundin JI"],"funding":["NCATS NIH HHS","NIDDK NIH HHS","NIA NIH HHS","NHLBI NIH HHS","NHGRI NIH HHS","NIH HHS","WHI NIH HHS"],"pagination":["120219"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12276907"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["407"],"pubmed_abstract":["<h4>Background and aims</h4>Cardiovascular disease (CVD) is one of the leading causes of morbidity and mortality worldwide, yet the underlying molecular mechanisms remain less understood. Chronic low-grade inflammation is a complex immune response contributing to the pathophysiology of cardiovascular disease. This response is signaled in part by interleukin-6 (IL-6), a pleiotropic, pro-inflammatory cytokine. Phenotypic variance in circulating IL-6 level may be explained in part by DNA methylation which is increasingly being associated with cardiovascular effects.<h4>Methods</h4>In this study we evaluated methylated DNA (CpG sites) associated with blood IL-6 levels across ∼4,400 ancestrally diverse individuals (81 % self-reported White; 9 % Black or African American, 8 % Hispanic or Latino/"],"journal":["Atherosclerosis"],"pubmed_title":["Epigenetic mechanisms underlying variation of IL-6, a well-established inflammation biomarker and risk factor for cardiovascular disease."],"pmcid":["PMC12276907"],"funding_grant_id":["N01 HC085083","N01 HC085082","N01 HC085081","N01 HC085086","UL1 TR001881","N01 HC095166","N01 HC095165","N01 HC095168","N01 HC095167","N01 HC085080","N01 HC095169","N01 HC095160","R01 AG023629","N01 HC095162","N01 HC095161","N01 HC095164","N01 HC095163","UL1 TR000040","HHSN268201500001C","75N92021D00001","75N92021D00002","75N92021D00003","UL1 TR000124","75N92021D00004","75N92021D00005","U54 HG003067","75N92021D00006","R01 HL120393","R01 HL116747","R01 HL076784","HHSN268200800007C","R01 HL092577","N01 HC055222","HHSN268201800001C","P30 DK063491","HHSN268201500001I","UL1 TR001420","R01 HG010297","U01 HL080295","R01 HL117626","R01 HL111089","U01 HL120393","N01 HC025195","75N92020D00007","HHSN268201200036C","75N92020D00001","75N92019D00031","S10 OD028685","75N92020D00002","75N92020D00005","75N92020D00006","75N92020D00003","75N92020D00004","R01 HL087652","R01 AG028321","HHSN268201500003C","UL1 TR001079","N01 HC095159","K08 HL116640","R01 HL092111","R01 HL103612","N01 HC085079","R01 HL105756","HHSN268201500003I","U01 HL130114"],"pubmed_authors":["Kasela S","Rotter JI","Van den Berg D","Hu Y","Guo X","Zhao W","Matise T","Ye T","Rich SS","Sotoodehnia N","Loos RJF","Haessler J","Liu Y","Peters U","Lappalainen T","Joehanes R","Smith JA","Lundin JI","Benjamin EJ","Park SL","PAGE Study","Cushman M","Haiman C","Reiner A","Raffield LM","Kenny E","Gignoux C","Ratliff SM","Bis JC","Tracy R","Ammous F","Brody JA","Levy D","Kooperberg C","Liu C","Fuller H","North KE"],"additional_accession":[]},"is_claimable":false,"name":"Epigenetic mechanisms underlying variation of IL-6, a well-established inflammation biomarker and risk factor for cardiovascular disease.","description":"<h4>Background and aims</h4>Cardiovascular disease (CVD) is one of the leading causes of morbidity and mortality worldwide, yet the underlying molecular mechanisms remain less understood. Chronic low-grade inflammation is a complex immune response contributing to the pathophysiology of cardiovascular disease. This response is signaled in part by interleukin-6 (IL-6), a pleiotropic, pro-inflammatory cytokine. Phenotypic variance in circulating IL-6 level may be explained in part by DNA methylation which is increasingly being associated with cardiovascular effects.<h4>Methods</h4>In this study we evaluated methylated DNA (CpG sites) associated with blood IL-6 levels across ∼4,400 ancestrally diverse individuals (81 % self-reported White; 9 % Black or African American, 8 % Hispanic or Latino/","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-07-15T08:57:13.051Z","creation":"2025-08-23T03:09:09.254Z"},"accession":"S-EPMC12276907","cross_references":{"pubmed":["40480020"],"doi":["10.1016/j.atherosclerosis.2025.120219"]}}