{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Xu H"],"pubmed_abstract":["<h4>Objective</h4>Most research reports on COVID-19 infections have focused on the correlation between the severity of the disease symptoms and immune deficits, while the mechanisms affecting the susceptibility to SARS-CoV-2 remain largely unknown. The study aimed to comprehensively analyze the differences in immunity, gut microbiota, metabolism, and proteomics between the SARS-CoV-2 resistant population and the susceptible population.<h4>Methods and results</h4>In this cohort comparison study, participants were rigorously selected based on inclusion and exclusion criteria in a continuous enrollment manner using combined questionnaires and clinical data, ultimately including 25 SARS-CoV-2 resistant volunteers versus 16 SARS-CoV-2 infected patients. The clinical information of the participa"],"journal":["Frontiers in medicine"],"pagination":["1593007"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12277166"],"repository":["biostudies-literature"],"pubmed_title":["Biological characteristics of SARS-CoV-2 resistant populations by integrated gut microbiota sequencing, metabolomics, and proteomics: a cohort comparison study."],"pmcid":["PMC12277166"],"pubmed_authors":["Li H","Chen Y","Deng L","Chen X","Xu H","Xu J","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Biological characteristics of SARS-CoV-2 resistant populations by integrated gut microbiota sequencing, metabolomics, and proteomics: a cohort comparison study.","description":"<h4>Objective</h4>Most research reports on COVID-19 infections have focused on the correlation between the severity of the disease symptoms and immune deficits, while the mechanisms affecting the susceptibility to SARS-CoV-2 remain largely unknown. The study aimed to comprehensively analyze the differences in immunity, gut microbiota, metabolism, and proteomics between the SARS-CoV-2 resistant population and the susceptible population.<h4>Methods and results</h4>In this cohort comparison study, participants were rigorously selected based on inclusion and exclusion criteria in a continuous enrollment manner using combined questionnaires and clinical data, ultimately including 25 SARS-CoV-2 resistant volunteers versus 16 SARS-CoV-2 infected patients. The clinical information of the participa","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-08-24T03:05:18Z","creation":"2025-08-24T03:05:18Z"},"accession":"S-EPMC12277166","cross_references":{"pubmed":["40692947"],"doi":["10.3389/fmed.2025.1593007"]}}