biostudies-literatureWong ENational University of Singapore Yong Loo Lin School of Medicine's Academic Fellowship Scheme, and the NUHS Clinician Scientist ProgramNUHS Seed FundNational University of Singapore Yong Loo Lin School of Medicine’s Academic Fellowship Scheme, and the NUHS Clinician Scientist ProgramAstra Zeneca, Abbott Technologies, and Boston ScientificNational Medical Research Council Research Training Fellowship26499https://www.ebi.ac.uk/biostudies/studies/S-EPMC12280198biostudies-literatureUnknown15(1)Patients with liver fibrosis and type 2 diabetes mellitus (T2DM) have an increased risk of cardiovascular events. However, long-term prognosis of liver fibrosis and T2DM after acute myocardial infarction (AMI) remain to be investigated. This study compared clinical characteristics and prognosis of AMI patients with T2DM and evidence of liver fibrosis. Patients were stratified into low, intermediate and high-risk for fibrosis, using serum-based non-invasive tests (NITs): Fibrosis-4 Index (FIB-4), Aspartate Aminotransferase to Platelet Ratio Index (APRI) and Non-alcoholic Fatty Liver Disease Fibrosis Score (NFS). The primary outcome was all-cause mortality, Kaplan-Meier curves were constructed for 5-year all-cause mortality. Cox regression analysis was used to determine the independent prediScientific reportsNon-invasive scoring systems of liver fibrosis predict prognosis in the cohort with myocardial infarction.PMC12280198speaker’s fees and research grantsMH 095:003/008-303NUHSRO/2022/058/RO5+6/Seed-Mar/03NCSP2.0/2024/NUHS/NCWSspeaker's fees and research grantsCao GMamas MAChong BChew NWKong GNah BLoh PHWong EJayabaskaran JMehta AChia JChan MYChen YZhang AMuthiah MfalseNon-invasive scoring systems of liver fibrosis predict prognosis in the cohort with myocardial infarction.Patients with liver fibrosis and type 2 diabetes mellitus (T2DM) have an increased risk of cardiovascular events. However, long-term prognosis of liver fibrosis and T2DM after acute myocardial infarction (AMI) remain to be investigated. This study compared clinical characteristics and prognosis of AMI patients with T2DM and evidence of liver fibrosis. Patients were stratified into low, intermediate and high-risk for fibrosis, using serum-based non-invasive tests (NITs): Fibrosis-4 Index (FIB-4), Aspartate Aminotransferase to Platelet Ratio Index (APRI) and Non-alcoholic Fatty Liver Disease Fibrosis Score (NFS). The primary outcome was all-cause mortality, Kaplan-Meier curves were constructed for 5-year all-cause mortality. Cox regression analysis was used to determine the independent predi2025-01-01T00:00:00Z2025 Jul2026-03-31T10:23:33.772Z2025-08-23T03:08:57.346ZS-EPMC122801984069126810.1038/s41598-025-12583-6