{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Ren Y"],"pubmed_abstract":["Epidural electrical stimulation (EES) has emerged as a promising treatment for spinal cord injury (SCI). However, the therapeutic potential of EES in functional recovery following incomplete SCI remains limited, with few studies of a large sample size. This study included 11 patients who received EES combined with physical therapy (PT) and 10 who received only PT. Follow-ups were conducted pre-surgery, post-surgery, and at 19 to 25 months postoperatively. After the surgery, patients in the EES + PT group showed significant improvements in sensory function (<i>P</i> < 0.001) and muscle spasticity (<i>P</i> < 0.001). Long-term follow-up indicated that the EES + PT group had significant improvements in sensory function (<i>P</i> < 0.001), muscle spasticity (<i>P</i> < 0.01), and urinary function (<i>P</i> < 0.05). Among them, all 11 patients had improvements in sensory function and muscle spasticity, and 6 of 11 reported an improvement in urinary function. Moreover, of the 5 patients with neuropathic pain, 4 exhibited reduced pain scores. Compared with the PT-only group, the EES + PT group had significantly better recovery in sensory function (<i>P</i> < 0.01), muscle spasticity (<i>P</i> < 0.0001), muscle strength (<i>P</i> < 0.01), and bowel function (<i>P</i> < 0.01). Further analysis suggested that patients with less severe SCIs in the EES + PT group tend to achieve better functional recovery. With a relatively large sample size compared to those in previous studies, this study confirms the promising therapeutic effects of EES in SCI. EES combined with PT provides a potential approach for functional recovery in patients with incomplete SCI."],"journal":["Cyborg and bionic systems (Washington, D.C.)"],"pagination":["0314"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12280331"],"repository":["biostudies-literature"],"pubmed_title":["Epidural Electrical Stimulation for Functional Recovery in Incomplete Spinal Cord Injury."],"pmcid":["PMC12280331"],"pubmed_authors":["Zhu P","Liang F","Ren Y","Lu J","Han X","Mo L","Jia W","Yin M","Zhao J"],"additional_accession":[]},"is_claimable":false,"name":"Epidural Electrical Stimulation for Functional Recovery in Incomplete Spinal Cord Injury.","description":"Epidural electrical stimulation (EES) has emerged as a promising treatment for spinal cord injury (SCI). However, the therapeutic potential of EES in functional recovery following incomplete SCI remains limited, with few studies of a large sample size. This study included 11 patients who received EES combined with physical therapy (PT) and 10 who received only PT. Follow-ups were conducted pre-surgery, post-surgery, and at 19 to 25 months postoperatively. After the surgery, patients in the EES + PT group showed significant improvements in sensory function (<i>P</i> < 0.001) and muscle spasticity (<i>P</i> < 0.001). Long-term follow-up indicated that the EES + PT group had significant improvements in sensory function (<i>P</i> < 0.001), muscle spasticity (<i>P</i> < 0.01), and urinary function (<i>P</i> < 0.05). Among them, all 11 patients had improvements in sensory function and muscle spasticity, and 6 of 11 reported an improvement in urinary function. Moreover, of the 5 patients with neuropathic pain, 4 exhibited reduced pain scores. Compared with the PT-only group, the EES + PT group had significantly better recovery in sensory function (<i>P</i> < 0.01), muscle spasticity (<i>P</i> < 0.0001), muscle strength (<i>P</i> < 0.01), and bowel function (<i>P</i> < 0.01). Further analysis suggested that patients with less severe SCIs in the EES + PT group tend to achieve better functional recovery. With a relatively large sample size compared to those in previous studies, this study confirms the promising therapeutic effects of EES in SCI. EES combined with PT provides a potential approach for functional recovery in patients with incomplete SCI.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-08-23T03:08:51.576Z","creation":"2025-08-23T03:08:51.576Z"},"accession":"S-EPMC12280331","cross_references":{"pubmed":["40697542"],"doi":["10.34133/cbsystems.0314"]}}