biostudies-literatureUnknown26(9)Zhang XM<h4>Objectives</h4>This systematic review and meta-analysis aimed to pool the effect size of the association between cognitive frailty and adverse outcomes (e.g., falls, disability, and hospitalization) among older adults.<h4>Design</h4>Systematic review and meta-analysis.<h4>Methods</h4>PubMed, ScienceDirect, and Embase were searched from their respective inceptions to June 1, 2022. We extracted prospective cohort studies that reported the association between cognitive frailty and adverse outcomes. Random or fixed-effects models based on heterogeneity were used to pool the effect sizes of independent associations of cognitive frailty, frailty only, and cognitive impairment only with each adverse outcome.<h4>Results</h4>Fifteen studies involving 49,122 older adults were included in the metThe journal of nutrition, health & aging817-825https://www.ebi.ac.uk/biostudies/studies/S-EPMC12280716biostudies-literatureAssociation between Cognitive Frailty and Adverse Outcomes among Older Adults: A Meta-Analysis.PMC12280716Cao JChen WWu XJZhang XMJiao JfalseAssociation between Cognitive Frailty and Adverse Outcomes among Older Adults: A Meta-Analysis.<h4>Objectives</h4>This systematic review and meta-analysis aimed to pool the effect size of the association between cognitive frailty and adverse outcomes (e.g., falls, disability, and hospitalization) among older adults.<h4>Design</h4>Systematic review and meta-analysis.<h4>Methods</h4>PubMed, ScienceDirect, and Embase were searched from their respective inceptions to June 1, 2022. We extracted prospective cohort studies that reported the association between cognitive frailty and adverse outcomes. Random or fixed-effects models based on heterogeneity were used to pool the effect sizes of independent associations of cognitive frailty, frailty only, and cognitive impairment only with each adverse outcome.<h4>Results</h4>Fifteen studies involving 49,122 older adults were included in the met2022-01-01T00:00:00Z20222026-03-31T10:32:59.664Z2025-08-24T03:07:22.686ZS-EPMC122807163615667310.1007/s12603-022-1833-5