biostudies-literatureUnknown8(4)Ochiai T<h4>Background</h4>Obesity and diabetes are well-established risk factors of Alzheimer's disease (AD). In the brains of patients with AD and model mice, diabetes-related factors have been implicated in the pathological changes of AD. However, the molecular mechanistic link between the peripheral metabolic state and AD pathophysiology have remained elusive. Endoplasmic reticulum (ER) stress is known as one of the major contributors to the metabolic abnormalities in obesity and diabetes. Interventions aimed at reducing ER stress have been shown to improve the systemic metabolic abnormalities, although their effects on the AD pathology have not been extensively studied.<h4>Objectives</h4>We examined whether interventions targeting ER stress attenuate the obesity/diabetes-induced Aβ accumulatiThe journal of prevention of Alzheimer's disease483-494https://www.ebi.ac.uk/biostudies/studies/S-EPMC12280779biostudies-literatureTauroursodeoxycholic Acid Attenuates Diet-Induced and Age-Related Peripheral Endoplasmic Reticulum Stress and Cerebral Amyloid Pathology in a Mouse Model of Alzheimer's Disease.PMC12280779Ochiai TWakabayashi TNagayama TIwatsubo TMatsui KAmano KSano TfalseTauroursodeoxycholic Acid Attenuates Diet-Induced and Age-Related Peripheral Endoplasmic Reticulum Stress and Cerebral Amyloid Pathology in a Mouse Model of Alzheimer's Disease.<h4>Background</h4>Obesity and diabetes are well-established risk factors of Alzheimer's disease (AD). In the brains of patients with AD and model mice, diabetes-related factors have been implicated in the pathological changes of AD. However, the molecular mechanistic link between the peripheral metabolic state and AD pathophysiology have remained elusive. Endoplasmic reticulum (ER) stress is known as one of the major contributors to the metabolic abnormalities in obesity and diabetes. Interventions aimed at reducing ER stress have been shown to improve the systemic metabolic abnormalities, although their effects on the AD pathology have not been extensively studied.<h4>Objectives</h4>We examined whether interventions targeting ER stress attenuate the obesity/diabetes-induced Aβ accumulati2021-01-01T00:00:00Z20212026-03-27T15:16:18.689Z2025-08-23T03:09:11.059ZS-EPMC122807793458522410.14283/jpad.2021.33