biostudies-literatureUnknown34Li Y<h4>Aims</h4>Existing evidence on the association between combined lifestyle and depressive symptoms is limited to the general population and is lacking in individuals with subthreshold depression, a high-risk group for depressive disorders. Furthermore, it remains unclear whether an overall healthy lifestyle can mitigate the association between childhood trauma (CT) and depressive symptoms, even in the general population. We aimed to explore the associations of combined lifestyle, and its interaction with CT, with depressive symptoms and their subtypes (i.e. cognitive-affective and somatic symptoms) among adults with subthreshold depression.<h4>Methods</h4>This dynamic cohort was initiated in Shenzhen, China in 2019, including adults aged 18-65 years with the Patient Health Questionnaire-Epidemiology and psychiatric sciencese39https://www.ebi.ac.uk/biostudies/studies/S-EPMC12281045biostudies-literatureCombined lifestyle, childhood trauma and depressive symptoms in adults with subthreshold depression: a prospective cohort study.PMC12281045Liao YHao JZhang HLu CHan XZhou WYiming SLi YLai WChen YWang WChen RZhao HfalseCombined lifestyle, childhood trauma and depressive symptoms in adults with subthreshold depression: a prospective cohort study.<h4>Aims</h4>Existing evidence on the association between combined lifestyle and depressive symptoms is limited to the general population and is lacking in individuals with subthreshold depression, a high-risk group for depressive disorders. Furthermore, it remains unclear whether an overall healthy lifestyle can mitigate the association between childhood trauma (CT) and depressive symptoms, even in the general population. We aimed to explore the associations of combined lifestyle, and its interaction with CT, with depressive symptoms and their subtypes (i.e. cognitive-affective and somatic symptoms) among adults with subthreshold depression.<h4>Methods</h4>This dynamic cohort was initiated in Shenzhen, China in 2019, including adults aged 18-65 years with the Patient Health Questionnaire-2025-01-01T00:00:00Z2025 Jul2026-03-16T07:43:01.798Z2025-08-15T03:06:05.983ZS-EPMC122810454066078210.1017/S2045796025100127