{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["49"],"submitter":["Pillonetto M"],"pubmed_abstract":["<h4>Background</h4>The rise of multidrug-resistant (MDR) bacteria represents a public health threat, with carbapenem resistance exacerbating this challenge. This study investigates carbapenemase-producing bacteria (CPB) across the Latin America and the Caribbean (LAC) region.<h4>Methods</h4>A retrospective observational study was conducted across 12 LAC countries from 2015 to 2020. A total of 58,909 isolates were analyzed utilizing polymerase chain reaction (PCR) to detect key carbapenemases in Enterobacterales, <i>Pseudomonas aeruginosa</i>, and <i>Acinetobacter baumannii</i> complex (ABC).<h4>Findings</h4>47,804/58,909 (81.14%) carbapenemases were identified, with Brazil accounting for 73% of these. The majority were reported in carbapenem-resistant Enterobacterales-CRE (65.33%; 31,230/47,804), followed by carbapenem-resistant ABC-CRAB (22.05%; 10,542/47,804), and carbapenem-resistant <i>P. aeruginosa</i>-CRPA (6050/47,804; 12.66%). Among CRE, <i>bla</i> <sub>KPC</sub> was the most detected gene (78.67%; 24,569/31,230), with <i>Klebsiella pneumoniae</i> being the most commonly associated species (75.9%). A relevant upward trend in <i>bla</i> <sub>NDM</sub> was observed. CRPA exhibited diverse profiles, with <i>bla</i> <sub>VIM</sub> (47.64%) being the most common. In CRAB, <i>bla</i> <sub>OXA-23</sub> was found in 88.80% (9361/10,542) of isolates. Carbapenemase co-production was detected in 2.60% (1190/47,804) of isolates, with CRPA <i>bla</i> <sub>IMP</sub> + <i>bla</i> <sub>VIM</sub> being the most frequent.<h4>Interpretation</h4>This study highlights a high prevalence of CPB in LAC, with a stable trend in <i>bla</i> <sub>KPC</sub> but a rising trend in <i>bla</i> <sub>NDM</sub>. These findings underscore the urgent need for strengthened surveillance and public health interventions to combat carbapenemase-mediated resistance in the region.<h4>Funding</h4>None."],"journal":["Lancet regional health. Americas"],"pagination":["101185"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12281157"],"repository":["biostudies-literature"],"pubmed_title":["Carbapenemases producing gram-negative bacteria surveillance in Latin America and the caribbean: a retrospective observational study from 2015 to 2020."],"pmcid":["PMC12281157"],"pubmed_authors":["Daniela Testoni CN","Helen C","Pardo PR","Mariel B","Vanessa Marcano PK","Andres H","Aparecida GG","Ronnie G","Carolina D","Baltodano HP","Diana FL","Elizondo AT","Kulek DNO","Silvia Scavacini MA","Galas M","Karla R","Mariana L","Julia Mazariegos HC","Ronaldo de J","Dianelys Q","T RTF","Carlos HJ","Leticia C","Victoria OM","Miorando R","Teresa IM","CARBA-LAC Group","Pillonetto M","Pamela A","Isaura Ugarte NC","Sati H","Satan SC","Wink PL","Thomas GR","Elizabeth T","Kiffer CRV","Saavedra Rojas SY","Melano RG","Carolina Sandoval LL","Miguel G","Luna BM","Abreu AL","Maria Avila AJ","D'Alincourt Carvalho Assef AP","Sofia B","Jimenez-Pearson MA","Melgarejo Touchet NL","Peral RT"],"additional_accession":[]},"is_claimable":false,"name":"Carbapenemases producing gram-negative bacteria surveillance in Latin America and the caribbean: a retrospective observational study from 2015 to 2020.","description":"<h4>Background</h4>The rise of multidrug-resistant (MDR) bacteria represents a public health threat, with carbapenem resistance exacerbating this challenge. This study investigates carbapenemase-producing bacteria (CPB) across the Latin America and the Caribbean (LAC) region.<h4>Methods</h4>A retrospective observational study was conducted across 12 LAC countries from 2015 to 2020. A total of 58,909 isolates were analyzed utilizing polymerase chain reaction (PCR) to detect key carbapenemases in Enterobacterales, <i>Pseudomonas aeruginosa</i>, and <i>Acinetobacter baumannii</i> complex (ABC).<h4>Findings</h4>47,804/58,909 (81.14%) carbapenemases were identified, with Brazil accounting for 73% of these. The majority were reported in carbapenem-resistant Enterobacterales-CRE (65.33%; 31,230/47,804), followed by carbapenem-resistant ABC-CRAB (22.05%; 10,542/47,804), and carbapenem-resistant <i>P. aeruginosa</i>-CRPA (6050/47,804; 12.66%). Among CRE, <i>bla</i> <sub>KPC</sub> was the most detected gene (78.67%; 24,569/31,230), with <i>Klebsiella pneumoniae</i> being the most commonly associated species (75.9%). A relevant upward trend in <i>bla</i> <sub>NDM</sub> was observed. CRPA exhibited diverse profiles, with <i>bla</i> <sub>VIM</sub> (47.64%) being the most common. In CRAB, <i>bla</i> <sub>OXA-23</sub> was found in 88.80% (9361/10,542) of isolates. Carbapenemase co-production was detected in 2.60% (1190/47,804) of isolates, with CRPA <i>bla</i> <sub>IMP</sub> + <i>bla</i> <sub>VIM</sub> being the most frequent.<h4>Interpretation</h4>This study highlights a high prevalence of CPB in LAC, with a stable trend in <i>bla</i> <sub>KPC</sub> but a rising trend in <i>bla</i> <sub>NDM</sub>. These findings underscore the urgent need for strengthened surveillance and public health interventions to combat carbapenemase-mediated resistance in the region.<h4>Funding</h4>None.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-03-18T14:13:15.641Z","creation":"2025-08-27T03:07:01.226Z"},"accession":"S-EPMC12281157","cross_references":{"pubmed":["40697529"],"doi":["10.1016/j.lana.2025.101185"]}}