{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(6)"],"submitter":["Guymer RH"],"pubmed_abstract":["<h4>Purpose</h4>To evaluate the effect of subthreshold nanosecond laser (SNL) treatment on the rate of loss of the OCT outer retinal bands in intermediate age-related macular degeneration (AMD).<h4>Design</h4>Post hoc analysis of the Laser Intervention in the Early Stages of AMD (LEAD) study.<h4>Participants</h4>A subset of 285 of 292 individuals in the LEAD study with bilateral large drusen without signs of multimodal imaging-defined late AMD at baseline, seen at 1 follow-up visit where neovascular AMD (nAMD) was absent.<h4>Methods</h4>Participants were randomized to receive SNL or sham treatment in 1 study eye at 6-monthly intervals and were reviewed for up to 36 months. OCT scans from all visits without nAMD were automatically segmented to examine between-group differences in the rate o"],"journal":["Ophthalmology science"],"pagination":["100839"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12281169"],"repository":["biostudies-literature"],"pubmed_title":["Effect of Subthreshold Nanosecond Laser on Loss of OCT Outer Retinal Bands in Age-Related Macular Degeneration: A LEAD Study Report."],"pmcid":["PMC12281169"],"pubmed_authors":["Williams M","Wright P","Sandhu S","Arunachalam S","Cuypers M","Harper CA","Young G","Forsyth T","Mather K","Toth L","McAllister I","Qatarneh D","Cunningham W","Caruso E","Douglas T","Isaacs T","Matthews R","Lingham G","Casalino G","Firibaldi M","Blair JPM","McGuinness M","Lavery NJ","Wickremasinghe S","Silvestri V","Sharangan P","Keller P","Chan D","Kolic M","Tindill N","Lin A","Radtke S","Aung KZ","Viljoen R","Barry C","Shalan B","Fagan X","Paley J","Cugley D","Shaw A","Lee K","Lee D","Tang I","Taori S","Busija L","Wong E","Harper C","Keenan J","Cheng M","Kelly L","Chang J","Guymer RH","Lek JJ","Heriot W","Runciman J","Chakravarthy U","Durkin S","Louis D","Kennelly K","Quinn M","Luu C","Vincent R","Vu H","Bryant J","Adams M","O'Day R","De Zanet S","Creese K","McIntosh R","Brown H","Lowe C","Wu Z","Xie D","Cohn A","Alessandrello E","Makeyeva G","Kandasamy R","Ghebrial V","Scullion L","Muecke J","Luckie A","Griffin S","Chen Y","Ayson H","Wu T","Shilton F","Apostolopoulos S","LEAD Study Group","Luscombe C","Chen M","Jason A","Chen F","Mangoris G","McKeone R","Busby T","Graham K","Boyle J","Constable I","Van Wijngaarden P","Cowles R","Sterrett G","Tan T","Denham R","Al-Qureshi S","Baglin E","Tan R","Lim SW","Balarantnasingam C","Gillvray K","Arnold J","Gihotra J","Brassington K","Koh L","Das R","Hodgson LAB","Razavi H","Peto T","McSweeney A","Graham A","Alessi-Calandro J","Haywood K","Robman L","Ciller C","Ong D","Nguyen T","Okada M","Cass H","Shanahan O","King A","Brko C","No S","Soloshenko A","Fitzsimons R","Smith M","Burns D","Nguyen A","Lim L","Blum R","Doyle L"],"additional_accession":[]},"is_claimable":false,"name":"Effect of Subthreshold Nanosecond Laser on Loss of OCT Outer Retinal Bands in Age-Related Macular Degeneration: A LEAD Study Report.","description":"<h4>Purpose</h4>To evaluate the effect of subthreshold nanosecond laser (SNL) treatment on the rate of loss of the OCT outer retinal bands in intermediate age-related macular degeneration (AMD).<h4>Design</h4>Post hoc analysis of the Laser Intervention in the Early Stages of AMD (LEAD) study.<h4>Participants</h4>A subset of 285 of 292 individuals in the LEAD study with bilateral large drusen without signs of multimodal imaging-defined late AMD at baseline, seen at 1 follow-up visit where neovascular AMD (nAMD) was absent.<h4>Methods</h4>Participants were randomized to receive SNL or sham treatment in 1 study eye at 6-monthly intervals and were reviewed for up to 36 months. OCT scans from all visits without nAMD were automatically segmented to examine between-group differences in the rate o","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov-Dec","modification":"2026-03-27T15:14:40.666Z","creation":"2025-08-23T03:09:06.111Z"},"accession":"S-EPMC12281169","cross_references":{"pubmed":["40697394"],"doi":["10.1016/j.xops.2025.100839"]}}