biostudies-literatureUnknown5(6)Guymer RH<h4>Purpose</h4>To evaluate the effect of subthreshold nanosecond laser (SNL) treatment on the rate of loss of the OCT outer retinal bands in intermediate age-related macular degeneration (AMD).<h4>Design</h4>Post hoc analysis of the Laser Intervention in the Early Stages of AMD (LEAD) study.<h4>Participants</h4>A subset of 285 of 292 individuals in the LEAD study with bilateral large drusen without signs of multimodal imaging-defined late AMD at baseline, seen at 1 follow-up visit where neovascular AMD (nAMD) was absent.<h4>Methods</h4>Participants were randomized to receive SNL or sham treatment in 1 study eye at 6-monthly intervals and were reviewed for up to 36 months. OCT scans from all visits without nAMD were automatically segmented to examine between-group differences in the rate oOphthalmology science100839https://www.ebi.ac.uk/biostudies/studies/S-EPMC12281169biostudies-literatureEffect of Subthreshold Nanosecond Laser on Loss of OCT Outer Retinal Bands in Age-Related Macular Degeneration: A LEAD Study Report.PMC12281169Williams MWright PSandhu SArunachalam SCuypers MHarper CAYoung GForsyth TMather KToth LMcAllister IQatarneh DCunningham WCaruso EDouglas TIsaacs TMatthews RLingham GCasalino GFiribaldi MBlair JPMMcGuinness MLavery NJWickremasinghe SSilvestri VSharangan PKeller PChan DKolic MTindill NLin ARadtke SAung KZViljoen RBarry CShalan BFagan XPaley JCugley DShaw ALee KLee DTang ITaori SBusija LWong EHarper CKeenan JCheng MKelly LChang JGuymer RHLek JJHeriot WRunciman JChakravarthy UDurkin SLouis DKennelly KQuinn MLuu CVincent RVu HBryant JAdams MO'Day RDe Zanet SCreese KMcIntosh RBrown HLowe CWu ZXie DCohn AAlessandrello EMakeyeva GKandasamy RGhebrial VScullion LMuecke JLuckie AGriffin SChen YAyson HWu TShilton FApostolopoulos SLEAD Study GroupLuscombe CChen MJason AChen FMangoris GMcKeone RBusby TGraham KBoyle JConstable IVan Wijngaarden PCowles RSterrett GTan TDenham RAl-Qureshi SBaglin ETan RLim SWBalarantnasingam CGillvray KArnold JGihotra JBrassington KKoh LDas RHodgson LABRazavi HPeto TMcSweeney AGraham AAlessi-Calandro JHaywood KRobman LCiller COng DNguyen TOkada MCass HShanahan OKing ABrko CNo SSoloshenko AFitzsimons RSmith MBurns DNguyen ALim LBlum RDoyle LfalseEffect of Subthreshold Nanosecond Laser on Loss of OCT Outer Retinal Bands in Age-Related Macular Degeneration: A LEAD Study Report.<h4>Purpose</h4>To evaluate the effect of subthreshold nanosecond laser (SNL) treatment on the rate of loss of the OCT outer retinal bands in intermediate age-related macular degeneration (AMD).<h4>Design</h4>Post hoc analysis of the Laser Intervention in the Early Stages of AMD (LEAD) study.<h4>Participants</h4>A subset of 285 of 292 individuals in the LEAD study with bilateral large drusen without signs of multimodal imaging-defined late AMD at baseline, seen at 1 follow-up visit where neovascular AMD (nAMD) was absent.<h4>Methods</h4>Participants were randomized to receive SNL or sham treatment in 1 study eye at 6-monthly intervals and were reviewed for up to 36 months. OCT scans from all visits without nAMD were automatically segmented to examine between-group differences in the rate o2025-01-01T00:00:00Z2025 Nov-Dec2026-03-27T15:14:40.666Z2025-08-23T03:09:06.111ZS-EPMC122811694069739410.1016/j.xops.2025.100839