{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wood ML"],"funding":["Scottish Funding Council","Medical Research Council","Chief Scientist Office","Wellcome Trust"],"pagination":["e0216024"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12282103"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["99(7)"],"pubmed_abstract":["Tens of millions of people worldwide have inherited chromosomally integrated human herpesvirus 6 (iciHHV-6), yet we know little about the consequences. iciHHV-6-positive individuals inherit the genome of HHV-6A or HHV-6B in the germline, and viral genomes are therefore present in every nucleated cell. To investigate the epidemiology of iciHHV-6 in the UK, almost 32,000 individuals were screened from two volunteer research studies: the family-based Generation Scotland: Scottish Family Health Study (GS:SFHS) and the Breakthrough Generations Study (BGS). iciHHV-6 prevalence in GS:SFHS was, to our knowledge, higher than that in other large studies at 2.74% (647/23,637), with an iciHHV-6B prevalence of 2.55%. Scottish participants were more likely to be iciHHV-6B-positive than English (<i>P</i>"],"journal":["Journal of virology"],"pubmed_title":["Inherited chromosomally integrated human herpesvirus 6: regional variation in prevalence, association with angina, and identification of ancestral viral lineages in two large UK studies."],"pmcid":["PMC12282103"],"funding_grant_id":["104036/Z/14/Z","HR03006","MC_UU_00007/10","CGA/16/31","CZD/16/6","MC_UU_12014/12","MR/T030941/1","MC_UU_12014/3"],"pubmed_authors":["Jarrett RF","Clark DA","Vattipally S","Kerr SM","Hunter LM","Fawkes A","Wilson JF","McConnachie A","Storrie S","Suarez NM","Murphy L","Swerdlow AJ","Howard P","Shaw E","Tomczyk K","Hughes J","Bell AJ","Hayward C","Wood ML","Tyne W","Delles C","Jones ME","Nichols J","Royle N","Lake A","Sweeney E","Stansilaus RP","Richmond A","Young R","Davison AJ","Orr N","Filipe AdS","Camiolo S","Brown K","Campbell A","Smollett K","Jesudason N","Brownlie C","Papageorgiou K","Zhu T"],"additional_accession":[]},"is_claimable":false,"name":"Inherited chromosomally integrated human herpesvirus 6: regional variation in prevalence, association with angina, and identification of ancestral viral lineages in two large UK studies.","description":"Tens of millions of people worldwide have inherited chromosomally integrated human herpesvirus 6 (iciHHV-6), yet we know little about the consequences. iciHHV-6-positive individuals inherit the genome of HHV-6A or HHV-6B in the germline, and viral genomes are therefore present in every nucleated cell. To investigate the epidemiology of iciHHV-6 in the UK, almost 32,000 individuals were screened from two volunteer research studies: the family-based Generation Scotland: Scottish Family Health Study (GS:SFHS) and the Breakthrough Generations Study (BGS). iciHHV-6 prevalence in GS:SFHS was, to our knowledge, higher than that in other large studies at 2.74% (647/23,637), with an iciHHV-6B prevalence of 2.55%. Scottish participants were more likely to be iciHHV-6B-positive than English (<i>P</i>","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-27T15:22:13.867Z","creation":"2025-08-23T03:08:58.004Z"},"accession":"S-EPMC12282103","cross_references":{"pubmed":["40470957"],"doi":["10.1128/jvi.02160-24"]}}