biostudies-literatureWood MLScottish Funding CouncilMedical Research CouncilChief Scientist OfficeWellcome Truste0216024https://www.ebi.ac.uk/biostudies/studies/S-EPMC12282103biostudies-literatureUnknown99(7)Tens of millions of people worldwide have inherited chromosomally integrated human herpesvirus 6 (iciHHV-6), yet we know little about the consequences. iciHHV-6-positive individuals inherit the genome of HHV-6A or HHV-6B in the germline, and viral genomes are therefore present in every nucleated cell. To investigate the epidemiology of iciHHV-6 in the UK, almost 32,000 individuals were screened from two volunteer research studies: the family-based Generation Scotland: Scottish Family Health Study (GS:SFHS) and the Breakthrough Generations Study (BGS). iciHHV-6 prevalence in GS:SFHS was, to our knowledge, higher than that in other large studies at 2.74% (647/23,637), with an iciHHV-6B prevalence of 2.55%. Scottish participants were more likely to be iciHHV-6B-positive than English (<i>P</i>Journal of virologyInherited chromosomally integrated human herpesvirus 6: regional variation in prevalence, association with angina, and identification of ancestral viral lineages in two large UK studies.PMC12282103104036/Z/14/ZHR03006MC_UU_00007/10CGA/16/31CZD/16/6MC_UU_12014/12MR/T030941/1MC_UU_12014/3Jarrett RFClark DAVattipally SKerr SMHunter LMFawkes AWilson JFMcConnachie AStorrie SSuarez NMMurphy LSwerdlow AJHoward PShaw ETomczyk KHughes JBell AJHayward CWood MLTyne WDelles CJones MENichols JRoyle NLake ASweeney EStansilaus RPRichmond AYoung RDavison AJOrr NFilipe AdSCamiolo SBrown KCampbell ASmollett KJesudason NBrownlie CPapageorgiou KZhu TfalseInherited chromosomally integrated human herpesvirus 6: regional variation in prevalence, association with angina, and identification of ancestral viral lineages in two large UK studies.Tens of millions of people worldwide have inherited chromosomally integrated human herpesvirus 6 (iciHHV-6), yet we know little about the consequences. iciHHV-6-positive individuals inherit the genome of HHV-6A or HHV-6B in the germline, and viral genomes are therefore present in every nucleated cell. To investigate the epidemiology of iciHHV-6 in the UK, almost 32,000 individuals were screened from two volunteer research studies: the family-based Generation Scotland: Scottish Family Health Study (GS:SFHS) and the Breakthrough Generations Study (BGS). iciHHV-6 prevalence in GS:SFHS was, to our knowledge, higher than that in other large studies at 2.74% (647/23,637), with an iciHHV-6B prevalence of 2.55%. Scottish participants were more likely to be iciHHV-6B-positive than English (<i>P</i>2025-01-01T00:00:00Z2025 Jul2026-03-27T15:22:13.867Z2025-08-23T03:08:58.004ZS-EPMC122821034047095710.1128/jvi.02160-24