{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou P"],"funding":["Earmarked Fund for China Agriculture Research System","Natural Science Foundation of Hubei Province","Fundamental Research Funds for the Central Universities","Postdoctoral Science Foundation of Hubei Province","National Natural Science Foundation of China","China Postdoctoral Science Foundation"],"pagination":["e0073525"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12282148"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["99(7)"],"pubmed_abstract":["The E3 ligase membrane-associated RING finger 6 (MARCH6) plays a pivotal role in various cellular processes; however, its role in viral defense remains largely unexplored. In this study, we have elucidated a novel antiviral mechanism of avian MARCH6 against duck Tembusu virus (TMUV), revealing a previously uncharacterized host defense strategy. Notably, MARCH6 expression was significantly upregulated during TMUV infection in several duck cell lines, suggesting a conserved cellular response. Functional analyses revealed that overexpression of MARCH6 effectively suppressed TMUV replication, whereas its knockdown markedly enhanced viral replication. Mechanistically, MARCH6 directly interacts with the viral non-structural protein 5 (NS5), mediating its targeted degradation through an unprecede"],"journal":["Journal of virology"],"pubmed_title":["MARCH6 suppresses Tembusu virus replication by targeting viral NS5 protein for TOLLIP-mediated selective autophagic degradation."],"pmcid":["PMC12282148"],"funding_grant_id":["2662023PY005","32272989","2024AFB125","2024HBBHCXA047","2024M761078","32402865","2025AFB600","GZC20230912","CARS-41"],"pubmed_authors":["Yang Y","Jin H","Zhou P","Xiao Y","Jongkaewwattana A","Wu W","Wei J","Zhou H","Luo R"],"additional_accession":[]},"is_claimable":false,"name":"MARCH6 suppresses Tembusu virus replication by targeting viral NS5 protein for TOLLIP-mediated selective autophagic degradation.","description":"The E3 ligase membrane-associated RING finger 6 (MARCH6) plays a pivotal role in various cellular processes; however, its role in viral defense remains largely unexplored. In this study, we have elucidated a novel antiviral mechanism of avian MARCH6 against duck Tembusu virus (TMUV), revealing a previously uncharacterized host defense strategy. Notably, MARCH6 expression was significantly upregulated during TMUV infection in several duck cell lines, suggesting a conserved cellular response. Functional analyses revealed that overexpression of MARCH6 effectively suppressed TMUV replication, whereas its knockdown markedly enhanced viral replication. Mechanistically, MARCH6 directly interacts with the viral non-structural protein 5 (NS5), mediating its targeted degradation through an unprecede","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-18T13:55:28.02Z","creation":"2025-08-21T09:53:03.314Z"},"accession":"S-EPMC12282148","cross_references":{"pubmed":["40511919"],"doi":["10.1128/jvi.00735-25"]}}