{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(7)"],"submitter":["Hao Q"],"pubmed_abstract":["Gut microbiota dysbiosis critically contributes to colitis-associated colorectal cancer (CAC) pathogenesis, positioning microbial modulation as a promising therapeutic strategy. <i>Weissella cibaria</i> (<i>W. cibaria</i>) is an emerging probiotic with potential cancer-inhibiting effects. This study investigates the anti-tumorigenic potential of <i>W. cibaria</i> in an azoxymethane/dextran sulfate sodium-induced CAC murine model. Mice were orally administered <i>W. cibaria</i> every 2 days from the beginning of the model construction until the end of the experiment. The study demonstrated significant changes in the gut microbiota of CAC mice, with a significant increase in the relative abundance of <i>Lactobacillaceae</i>. Supplementation with <i>W. cibaria</i> restored the intestinal barr"],"journal":["mSystems"],"pagination":["e0028825"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12282153"],"repository":["biostudies-literature"],"pubmed_title":["&lt;i&gt;Weissella cibaria&lt;/i&gt; suppresses colitis-associated colorectal cancer by modulating the gut microbiota-bile acid-FXR axis."],"pmcid":["PMC12282153"],"pubmed_authors":["Huang F","Chang L","Hao Q","Yao Y","Chen W","Zhen Y","Dai H"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;Weissella cibaria&lt;/i&gt; suppresses colitis-associated colorectal cancer by modulating the gut microbiota-bile acid-FXR axis.","description":"Gut microbiota dysbiosis critically contributes to colitis-associated colorectal cancer (CAC) pathogenesis, positioning microbial modulation as a promising therapeutic strategy. <i>Weissella cibaria</i> (<i>W. cibaria</i>) is an emerging probiotic with potential cancer-inhibiting effects. This study investigates the anti-tumorigenic potential of <i>W. cibaria</i> in an azoxymethane/dextran sulfate sodium-induced CAC murine model. Mice were orally administered <i>W. cibaria</i> every 2 days from the beginning of the model construction until the end of the experiment. The study demonstrated significant changes in the gut microbiota of CAC mice, with a significant increase in the relative abundance of <i>Lactobacillaceae</i>. Supplementation with <i>W. cibaria</i> restored the intestinal barr","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-17T15:40:17.646Z","creation":"2025-08-23T03:04:55.566Z"},"accession":"S-EPMC12282153","cross_references":{"pubmed":["40607831"],"doi":["10.1128/msystems.00288-25"]}}