biostudies-literatureUnknown10(7)Hao QGut microbiota dysbiosis critically contributes to colitis-associated colorectal cancer (CAC) pathogenesis, positioning microbial modulation as a promising therapeutic strategy. <i>Weissella cibaria</i> (<i>W. cibaria</i>) is an emerging probiotic with potential cancer-inhibiting effects. This study investigates the anti-tumorigenic potential of <i>W. cibaria</i> in an azoxymethane/dextran sulfate sodium-induced CAC murine model. Mice were orally administered <i>W. cibaria</i> every 2 days from the beginning of the model construction until the end of the experiment. The study demonstrated significant changes in the gut microbiota of CAC mice, with a significant increase in the relative abundance of <i>Lactobacillaceae</i>. Supplementation with <i>W. cibaria</i> restored the intestinal barrmSystemse0028825https://www.ebi.ac.uk/biostudies/studies/S-EPMC12282153biostudies-literature&lt;i&gt;Weissella cibaria&lt;/i&gt; suppresses colitis-associated colorectal cancer by modulating the gut microbiota-bile acid-FXR axis.PMC12282153Huang FChang LHao QYao YChen WZhen YDai Hfalse&lt;i&gt;Weissella cibaria&lt;/i&gt; suppresses colitis-associated colorectal cancer by modulating the gut microbiota-bile acid-FXR axis.Gut microbiota dysbiosis critically contributes to colitis-associated colorectal cancer (CAC) pathogenesis, positioning microbial modulation as a promising therapeutic strategy. <i>Weissella cibaria</i> (<i>W. cibaria</i>) is an emerging probiotic with potential cancer-inhibiting effects. This study investigates the anti-tumorigenic potential of <i>W. cibaria</i> in an azoxymethane/dextran sulfate sodium-induced CAC murine model. Mice were orally administered <i>W. cibaria</i> every 2 days from the beginning of the model construction until the end of the experiment. The study demonstrated significant changes in the gut microbiota of CAC mice, with a significant increase in the relative abundance of <i>Lactobacillaceae</i>. Supplementation with <i>W. cibaria</i> restored the intestinal barr2025-01-01T00:00:00Z2025 Jul2026-03-17T15:40:17.646Z2025-08-23T03:04:55.566ZS-EPMC122821534060783110.1128/msystems.00288-25