{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wei YY"],"funding":["Anhui Medical University","National Natural Science Foundation of China","research and practice innovation project of graduate students of Anhui Medical University","clinical medical research and transformation project of Anhui Province"],"pagination":["1717-1743"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12283003"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(8)"],"pubmed_abstract":["Microplastics (MPs) induce mitochondrial dysfunction and iron accumulation, contributing to mitochondrial macroautophagy/autophagy and ferroptosis, which has increased susceptibility to the exacerbation of chronic obstructive pulmonary disease (COPD); however, the underlying mechanism remains unclear. We demonstrated that MPs intensified inflammation in COPD by enhancing autophagy-dependent ferroptosis (ADF) in vitro and in vivo. In the lung tissues of patients with COPD, the concentrations of MPs, especially polystyrene microplastics (PS-MPs), were significantly higher than that of the control group, as detected by pyrolysis gas chromatography mass spectrometry (Py-GCMS), with increased iron accumulation. The exposure to PS-MPs, 2 μm in size, resulted in their being deposited in the lungs"],"journal":["Autophagy"],"pubmed_title":["Microplastics exacerbate ferroptosis via mitochondrial reactive oxygen species-mediated autophagy in chronic obstructive pulmonary disease."],"pmcid":["PMC12283003"],"funding_grant_id":["YJS20230121","202304295107020038","82170050"],"pubmed_authors":["Wei YY","Zhang DW","Chen KG","Fei GH","Zhang Y","Li F","Wang MY","Chen TT","Zhang L","Ding YC"],"additional_accession":[]},"is_claimable":false,"name":"Microplastics exacerbate ferroptosis via mitochondrial reactive oxygen species-mediated autophagy in chronic obstructive pulmonary disease.","description":"Microplastics (MPs) induce mitochondrial dysfunction and iron accumulation, contributing to mitochondrial macroautophagy/autophagy and ferroptosis, which has increased susceptibility to the exacerbation of chronic obstructive pulmonary disease (COPD); however, the underlying mechanism remains unclear. We demonstrated that MPs intensified inflammation in COPD by enhancing autophagy-dependent ferroptosis (ADF) in vitro and in vivo. In the lung tissues of patients with COPD, the concentrations of MPs, especially polystyrene microplastics (PS-MPs), were significantly higher than that of the control group, as detected by pyrolysis gas chromatography mass spectrometry (Py-GCMS), with increased iron accumulation. The exposure to PS-MPs, 2 μm in size, resulted in their being deposited in the lungs","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-03-31T10:31:52.742Z","creation":"2025-08-23T03:09:21.766Z"},"accession":"S-EPMC12283003","cross_references":{"pubmed":["40114310"],"doi":["10.1080/15548627.2025.2481126"]}}