{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Bergamino M"],"pubmed_abstract":["<h4>Introduction</h4>Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms. Levodopa remains the primary treatment, temporarily restoring dopamine levels and improving motor symptoms. Advanced diffusion MRI techniques, such as free-water corrected diffusion tensor imaging (fw-DTI) and neurite orientation dispersion and density imaging (NODDI), provide insights into PD-related microstructural changes beyond conventional DTI.<h4>Methods</h4>This study investigates white matter alterations in PD using multi-shell fw-DTI and NODDI to compare voxel-wise differences between PD patients both OFF and ON levodopa, with comparison to healthy controls (HC). Effect sizes and receiver operating characteristic (ROC) analyses assessed the discr"],"journal":["Frontiers in neurology"],"pagination":["1605753"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12283281"],"repository":["biostudies-literature"],"pubmed_title":["Investigating white matter alterations in Parkinson's disease using multi-shell free-water DTI and NODDI: insights into neurodegeneration and levodopa effects."],"pmcid":["PMC12283281"],"pubmed_authors":["Stokes AM","Bergamino M","Shill HA","Zhu S"],"additional_accession":[]},"is_claimable":false,"name":"Investigating white matter alterations in Parkinson's disease using multi-shell free-water DTI and NODDI: insights into neurodegeneration and levodopa effects.","description":"<h4>Introduction</h4>Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms. Levodopa remains the primary treatment, temporarily restoring dopamine levels and improving motor symptoms. Advanced diffusion MRI techniques, such as free-water corrected diffusion tensor imaging (fw-DTI) and neurite orientation dispersion and density imaging (NODDI), provide insights into PD-related microstructural changes beyond conventional DTI.<h4>Methods</h4>This study investigates white matter alterations in PD using multi-shell fw-DTI and NODDI to compare voxel-wise differences between PD patients both OFF and ON levodopa, with comparison to healthy controls (HC). Effect sizes and receiver operating characteristic (ROC) analyses assessed the discr","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-03-16T05:29:36.326Z","creation":"2025-08-14T03:06:13.019Z"},"accession":"S-EPMC12283281","cross_references":{"pubmed":["40703778"],"doi":["10.3389/fneur.2025.1605753"]}}