{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["German J"],"funding":["NCATS NIH HHS","European Research Council","NIDDK NIH HHS","NIMH NIH HHS","Eesti Teadusagentuur (Estonian Research Council)","NHGRI NIH HHS","Broad Institute"],"pagination":["2269-2276"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12283387"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(7)"],"pubmed_abstract":["Obesity is a major public health challenge. Glucagon-like peptide-1 receptor agonists (GLP1-RA) and bariatric surgery (BS) are effective weight loss interventions; however, the genetic factors influencing treatment response remain largely unexplored. Moreover, most previous studies have focused on race and ethnicity rather than genetic ancestry. Here we analyzed 10,960 individuals from 9 multiancestry biobank studies across 6 countries to assess the impact of known genetic factors on weight loss. Between 6 and 12 months, GLP1-RA users had an average weight change of -3.93% or -6.00%, depending on the outcome definition, with modest ancestry-based differences. BS patients experienced -21.17% weight change between 6 and 48 months. We found no significant associations between GLP1-RA-induced "],"journal":["Nature medicine"],"pubmed_title":["Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery."],"pmcid":["PMC12283387"],"funding_grant_id":["R01 MH115676","PSG759","101117251","Eric and Wendy Schmidt Center Fellowship","UL1 TR001881","R01 HG009120","K23 DK131345","U01 HG011715"],"pubmed_authors":["Urbut S","Kutalik Z","Mohammed S","Barry A","Corbetta A","Hail MA","Lee J","Vainik U","Ripatti S","Loos RJF","Tozzo V","Saad C","Ding Y","Philippakis A","Abdel-Latif R","Szczerbinski L","Janucik A","Cordioli M","Al-Sarraj Y","Wang Z","Natarajan P","Eoli A","Smit RAJ","Cajuso T","Ganna A","Mbarek H","German J","Akinkuolie A","Pasaniuc B","Heyne HO","Li JH","Arumae K"],"additional_accession":[]},"is_claimable":false,"name":"Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery.","description":"Obesity is a major public health challenge. Glucagon-like peptide-1 receptor agonists (GLP1-RA) and bariatric surgery (BS) are effective weight loss interventions; however, the genetic factors influencing treatment response remain largely unexplored. Moreover, most previous studies have focused on race and ethnicity rather than genetic ancestry. Here we analyzed 10,960 individuals from 9 multiancestry biobank studies across 6 countries to assess the impact of known genetic factors on weight loss. Between 6 and 12 months, GLP1-RA users had an average weight change of -3.93% or -6.00%, depending on the outcome definition, with modest ancestry-based differences. BS patients experienced -21.17% weight change between 6 and 48 months. We found no significant associations between GLP1-RA-induced ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-16T08:17:32.203Z","creation":"2025-08-15T03:06:18.877Z"},"accession":"S-EPMC12283387","cross_references":{"pubmed":["40251273"],"doi":["10.1038/s41591-025-03645-3"]}}