{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Wang Y"],"pubmed_abstract":["<h4>Introduction</h4>Recent studies have underscored the role of interactions between Traditional Chinese Medicine (TCM) and the gut microbiome (GM) in mediating therapeutic effects. Jian-Pi-Yi-Shen Formula (JPYSF) has shown efficacy in ameliorating chronic kidney disease (CKD) symptoms, but its mechanisms via GM modulation remain unclear.<h4>Methods</h4>In this study, 8-week-old rats were assigned to three groups after a two-week acclimation: C (normal diet for six weeks), M (adenine diet for four weeks then normal diet for two weeks), and T (same as M, with JPYSF administered during the final three weeks). Fecal samples were collected at three timepoints (T1: post-acclimation; T2: after three weeks on respective diets; T3: after three weeks of JPYSF treatment) for metagenomic sequencing."],"journal":["Frontiers in cellular and infection microbiology"],"pagination":["1526863"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12283701"],"repository":["biostudies-literature"],"pubmed_title":["Jian-Pi-Yi-Shen formula improves kidney function by regulating gut microbiome in rats with chronic kidney disease."],"pmcid":["PMC12283701"],"pubmed_authors":["Lu J","Dai W","Wang Y","Yang S"],"additional_accession":[]},"is_claimable":false,"name":"Jian-Pi-Yi-Shen formula improves kidney function by regulating gut microbiome in rats with chronic kidney disease.","description":"<h4>Introduction</h4>Recent studies have underscored the role of interactions between Traditional Chinese Medicine (TCM) and the gut microbiome (GM) in mediating therapeutic effects. Jian-Pi-Yi-Shen Formula (JPYSF) has shown efficacy in ameliorating chronic kidney disease (CKD) symptoms, but its mechanisms via GM modulation remain unclear.<h4>Methods</h4>In this study, 8-week-old rats were assigned to three groups after a two-week acclimation: C (normal diet for six weeks), M (adenine diet for four weeks then normal diet for two weeks), and T (same as M, with JPYSF administered during the final three weeks). Fecal samples were collected at three timepoints (T1: post-acclimation; T2: after three weeks on respective diets; T3: after three weeks of JPYSF treatment) for metagenomic sequencing.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-03-16T04:21:20.129Z","creation":"2025-08-14T03:05:53.086Z"},"accession":"S-EPMC12283701","cross_references":{"pubmed":["40703671"],"doi":["10.3389/fcimb.2025.1526863"]}}