biostudies-literatureChen XThe Joint Funds for the Innovation of Science and Technology, Fujian ProvinceFujian Provincial Health Technology ProjectNatural Science Foundation of Fujian ProvinceNational Natural Science Foundation of China3165-3172https://www.ebi.ac.uk/biostudies/studies/S-EPMC12283799biostudies-literatureUnknown104(6)Thrombotic thrombocytopenic purpura (TTP) is a rare but fatal disease requiring urgent diagnosis. The PLASMIC scoring model has been reported to be a valuable model for identifying TTP. This study aimed to investigate the diagnostic accuracy of this model and the diagnostic utility of lactate dehydrogenase (LDH)-to-serum creatinine (sCr) ratio in identifying TTP in Chinese patients. The records of 61 patients with suspected TTP tested for ADAMTS13 activity in our hospital between June 2016 and April 2024 were retrospectively analyzed. Receiver operating characteristic (ROC) analysis was performed to evaluate the diagnostic accuracy of LDH, sCr, and the LDH-to-sCr (LDH/sCr) in predicting TTP. Multivariate logistic regression analysis was used to screen for independent risk factors of TTP, aAnnals of hematologyA predictive algorithm involving lactate dehydrogenase to serum creatinine ratio may assist in identifying patients with thrombotic thrombocytopenic purpura.PMC122837992024Y9274820701172020Y90722024GGA0152018J013122021J01753Li WCai RWu ZZhang JFu JLin XChen XLuo XWei LfalseA predictive algorithm involving lactate dehydrogenase to serum creatinine ratio may assist in identifying patients with thrombotic thrombocytopenic purpura.Thrombotic thrombocytopenic purpura (TTP) is a rare but fatal disease requiring urgent diagnosis. The PLASMIC scoring model has been reported to be a valuable model for identifying TTP. This study aimed to investigate the diagnostic accuracy of this model and the diagnostic utility of lactate dehydrogenase (LDH)-to-serum creatinine (sCr) ratio in identifying TTP in Chinese patients. The records of 61 patients with suspected TTP tested for ADAMTS13 activity in our hospital between June 2016 and April 2024 were retrospectively analyzed. Receiver operating characteristic (ROC) analysis was performed to evaluate the diagnostic accuracy of LDH, sCr, and the LDH-to-sCr (LDH/sCr) in predicting TTP. Multivariate logistic regression analysis was used to screen for independent risk factors of TTP, a2025-01-01T00:00:00Z2025 Jun2026-03-16T08:16:35.083Z2025-08-14T03:06:00.142ZS-EPMC122837994054283310.1007/s00277-025-06472-1