biostudies-literatureUnknownFaizy TDNINR NIH HHSNINDS NIH HHSNIGMS NIH HHS<h4>Background</h4>Current randomized controlled trials are investigating the efficacy and safety of mechanical thrombectomy (MT) in patients with medium vessel occlusion (MeVO) stroke. Whether best medical management (MM) is more efficient than unsuccessful vessel recanalization during MT remains unknown.<h4>Methods</h4>This was a retrospective cohort study using data from 37 academic centers across North America, Asia, and Europe between September 2017 and July 2021. Only patients with occlusion of the distal branches (M2 and M3) of the middle cerebral artery territory were included. Unsuccessful MT was defined as a modified Thrombolysis in Cerebral Infarction score of 0-2a. Propensity score matching was used to control for confounders. The primary outcome was functional independence, deJournal of neurointerventional surgeryjnis-2024-022642https://www.ebi.ac.uk/biostudies/studies/S-EPMC12284089biostudies-literatureClinical outcomes of patients with unsuccessful mechanical thrombectomy versus best medical management of medium vessel occlusion stroke in the middle cerebral artery territory.PMC12284089U24 NS113844R21 NR020231U54 GM104942R21 NS131756Mendes Pereira VPedicelli AFilipe JPGonzalez NMohlenbruch MADaraghma MBarreau XYedavalli VFahed RQuintero-Consuegra MSpears JFaizy TDShaikh HBiswas ASalazar-Marioni SMarnat GHenninger NGuenego AKuhn ALBellante FVagal AKalsoum EDmytriw AAColasurdo MAbdalkader MHeit JJSiegler JECancelliere NMLakhani DAClarencon FRenieri LYeo LLBerge JAliAziz-Sultan MKlein PForestier GMusmar BStapleton CJEl Naamani KHecker CWintermark MFiehler JElhorany MSchiphorst ATMph KGriessenauer CJDofuku SHarker PPremat KCostalat VScarcia LCapirossi CVarela RBaker AGopinathan ARegenhardt RWKadirvel RLiebeskind DSHsieh CYWeyland CMounayer CEssibayi MAMartinez-Gutierrez JCSheth SAMowla AKiller-Oberpfalzer MPuri ASRabinov JDMeyer LKhalife JMAD-MT InvestigatorsAltschul DTan BYStracke CPTancredi IAmllay AOta TJesser JDyzmann CPhD ISHugo HGory BLubicz BValente IJabbour PAziz YKhandelwal PRadu RAAdeeb NPatel ABNguyen TNNedelcu STjoumakaris SIGhozy SThomas AJSundararajan SHMarotta TRDusart ASalim HAChervak LSaleme SAlexandre AMRouchaud APeter TfalseClinical outcomes of patients with unsuccessful mechanical thrombectomy versus best medical management of medium vessel occlusion stroke in the middle cerebral artery territory.<h4>Background</h4>Current randomized controlled trials are investigating the efficacy and safety of mechanical thrombectomy (MT) in patients with medium vessel occlusion (MeVO) stroke. Whether best medical management (MM) is more efficient than unsuccessful vessel recanalization during MT remains unknown.<h4>Methods</h4>This was a retrospective cohort study using data from 37 academic centers across North America, Asia, and Europe between September 2017 and July 2021. Only patients with occlusion of the distal branches (M2 and M3) of the middle cerebral artery territory were included. Unsuccessful MT was defined as a modified Thrombolysis in Cerebral Infarction score of 0-2a. Propensity score matching was used to control for confounders. The primary outcome was functional independence, de2025-01-01T00:00:00Z2025 Jan2026-03-16T05:41:28.674Z2025-08-14T03:06:22.143ZS-EPMC122840893985567410.1136/jnis-2024-022642