biostudies-literatureUnknown7(3)Mass H<h4>Objective</h4>Intra-articular injections (IAI) are commonly used to treat knee pain in persons with knee osteoarthritis (OA). We sought to determine the value of commonly used IAIs in knee OA management.<h4>Methods</h4>We used the validated Osteoarthritis Policy Model (OAPol) to assess the value of saline, corticosteroid (CS), hyaluronic acid (HA), and platelet-rich plasma (PRP) IAIs in knee OA management. We conducted a meta-analysis of high quality studies to estimate IAI-specific pain reduction. We assumed that repeat CS injections increase the risk of OA progression threefold in the base case. We determined the value of specific IAIs with incremental cost-effectiveness ratios (ICERs). We conducted sensitivity analyses to account for uncertainty in input parameters.<h4>Results</h4>IOsteoarthritis and cartilage open100641https://www.ebi.ac.uk/biostudies/studies/S-EPMC12284352biostudies-literatureIntra-articular injections for knee osteoarthritis management: Analysis of cost-effectiveness.PMC12284352Neogi TMessier SPLosina EJones MHTsai LKatz JNCollins JEYang CHunter DJMass HfalseIntra-articular injections for knee osteoarthritis management: Analysis of cost-effectiveness.<h4>Objective</h4>Intra-articular injections (IAI) are commonly used to treat knee pain in persons with knee osteoarthritis (OA). We sought to determine the value of commonly used IAIs in knee OA management.<h4>Methods</h4>We used the validated Osteoarthritis Policy Model (OAPol) to assess the value of saline, corticosteroid (CS), hyaluronic acid (HA), and platelet-rich plasma (PRP) IAIs in knee OA management. We conducted a meta-analysis of high quality studies to estimate IAI-specific pain reduction. We assumed that repeat CS injections increase the risk of OA progression threefold in the base case. We determined the value of specific IAIs with incremental cost-effectiveness ratios (ICERs). We conducted sensitivity analyses to account for uncertainty in input parameters.<h4>Results</h4>I2025-01-01T00:00:00Z2025 Sep2026-03-16T04:44:17.58Z2025-08-15T03:06:15.27ZS-EPMC122843524070353710.1016/j.ocarto.2025.100641