biostudies-literatureUnknown36(3)Borsos BNBreast cancer (BC) is the most prevalent cancer among women globally. Identifying BC at its early stage is of significant importance; however, due to the limited resolution and the accompanying adverse events of the current detection methods, including mammography, in clinical practice, it remains challenging. Minimally invasive screening would be a promising solution to overcome these constraints. In the current study, we identified serum microRNAs (miRNAs) that could serve as potential targets for recognizing early-stage BC. We quantitatively measured the expression changes of 14 miRNAs in the blood sera of our study cohort that enrolled 59 patients with BC and 42 healthy volunteers. Subsequently, we selected the most prominent correlated multiple miRNAs that can discriminate well betweeMolecular therapy. Nucleic acids102621https://www.ebi.ac.uk/biostudies/studies/S-EPMC12284516biostudies-literatureExploring potent miRNA combinations for detecting early-stage breast cancer.PMC12284516Borsos BNPankotai TPahi ZGfalseExploring potent miRNA combinations for detecting early-stage breast cancer.Breast cancer (BC) is the most prevalent cancer among women globally. Identifying BC at its early stage is of significant importance; however, due to the limited resolution and the accompanying adverse events of the current detection methods, including mammography, in clinical practice, it remains challenging. Minimally invasive screening would be a promising solution to overcome these constraints. In the current study, we identified serum microRNAs (miRNAs) that could serve as potential targets for recognizing early-stage BC. We quantitatively measured the expression changes of 14 miRNAs in the blood sera of our study cohort that enrolled 59 patients with BC and 42 healthy volunteers. Subsequently, we selected the most prominent correlated multiple miRNAs that can discriminate well betwee2025-01-01T00:00:00Z2025 Sep2026-03-15T17:32:33.332Z2025-08-14T03:05:17.993ZS-EPMC122845164070402710.1016/j.omtn.2025.102621