biostudies-literatureSong JMedical Science and Technology Project of Zhejiang ProvinceShanghai Pudong New Area Health CommissionKey Research and Development Program of Zhejiang Province105https://www.ebi.ac.uk/biostudies/studies/S-EPMC12287484biostudies-literatureUnknown15(1)<h4>Background</h4>Venous congestion is associated with adverse clinical outcomes in critically ill patients, yet its assessment remains challenging. Recently, the Venous Excess Ultrasound (VExUS) score has shown great potential as a non-invasive tool for assessing venous congestion in cardiac patients. However, the relationship between VExUS and clinical outcomes in patients with sepsis remains understudied. This study aims to evaluate the incidence of venous congestion based on VExUS assessment within the first 5 days of intensive care unit (ICU) admission in critically ill patients with sepsis, and to investigate the association between VExUS and clinical outcomes.<h4>Methods</h4>We conducted a prospective, observational study in four ICUs, enrolling adult patients with sepsis who stayeAnnals of intensive careAssociation between the Venous Excess Ultrasound (VExUS) score and acute kidney injury in critically ill patients with sepsis: a multicenter prospective observational study.PMC122874842024C03240PWZzb2022-212023KY004PWRd2022-14Wang MHu CLuo QFan HGong SLai DHu WChen GChen WSong JZhong LMing ZfalseAssociation between the Venous Excess Ultrasound (VExUS) score and acute kidney injury in critically ill patients with sepsis: a multicenter prospective observational study.<h4>Background</h4>Venous congestion is associated with adverse clinical outcomes in critically ill patients, yet its assessment remains challenging. Recently, the Venous Excess Ultrasound (VExUS) score has shown great potential as a non-invasive tool for assessing venous congestion in cardiac patients. However, the relationship between VExUS and clinical outcomes in patients with sepsis remains understudied. This study aims to evaluate the incidence of venous congestion based on VExUS assessment within the first 5 days of intensive care unit (ICU) admission in critically ill patients with sepsis, and to investigate the association between VExUS and clinical outcomes.<h4>Methods</h4>We conducted a prospective, observational study in four ICUs, enrolling adult patients with sepsis who staye2025-01-01T00:00:00Z2025 Jul2026-03-17T15:34:25.542Z2025-08-17T03:05:58.614ZS-EPMC122874844069927310.1186/s13613-025-01529-w