{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Sun L"],"pubmed_abstract":["The link between serum glucose-potassium ratio (GPR) and mortality in critically ill toxic encephalopathy (TE) patients is not well defined. This study has aimed to clarify the effect of GPR fluctuations on TE mortality. A total of 3,462 TE patients with TE requiring ICU care were selected from the Medical Information Mart Intensive Care (MIMIC-IV) database. Patients were categorized into three groups based on GPR tertiles: Tertile 1 (n = 1154, range 0.103-1.442), Tertile 2 (n = 1153, range 1.444-1.966), and Tertile 3 (n = 1155, range 1.967-12.937). The primary outcomes studied were 28-day and 90-day all-cause mortality (ACM). To analyze the relationship between GPR and outcomes, we employed Cox regression models adjusted for multiple covariates and restricted cubic splines to explore the potential non-linear association. The 3,462 - patient cohort had a mean age of 67.7 ± 16.6 years, with 58.2% male. The 28-day and 90-day ACM were 21.9% and 31.2%, respectively. Multivariate adjusted analysis showed no overall GPR-ACM correlation at 28 and 90 d. Regarding different groups, with T2 as the reference group (Ref), for 28-day ACM, the adjusted hazard ratio (HR) of the T1 was 1.20 (95% Confidence Interval [CI]: 1.00-1.44, p ≡ P = 0.049), and that of T3 group was 1.22 (95% CI: 1.01-1.47, P = 0.035). For 90 - day ACM, the adjusted HR of the T1 was 1.19 (95% CI: 1.02-1.39, P = 0.023), and the T3 was 1.20 (95% CI: 1.03-1.40). The correlation between the GPR lesvel and ACM was U-shaped association. The left and right - hand side effect sizes at the inflection point (1.65) were 0.472 (HR: 0.472, 95% CI 0.306-0.728, P < 0.001) and 1.127 (HR: 1.127, 95% CI 1.032-1.229, P = 0.0075). Sensitivity analysis was stable. Our findings have revealed a U-shaped relationship between GPR levels and ACM in critically ill patients with TE. Close attention should therefore be paid to this issue in order to improve patient care."],"journal":["Scientific reports"],"pagination":["26795"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12287516"],"repository":["biostudies-literature"],"pubmed_title":["U shaped relationship between serum glucose potassium ratio and mortality in critically ill patients with toxic encephalopathy."],"pmcid":["PMC12287516"],"pubmed_authors":["Sun L","Shao F","Jin P","Liu T"],"additional_accession":[]},"is_claimable":false,"name":"U shaped relationship between serum glucose potassium ratio and mortality in critically ill patients with toxic encephalopathy.","description":"The link between serum glucose-potassium ratio (GPR) and mortality in critically ill toxic encephalopathy (TE) patients is not well defined. This study has aimed to clarify the effect of GPR fluctuations on TE mortality. A total of 3,462 TE patients with TE requiring ICU care were selected from the Medical Information Mart Intensive Care (MIMIC-IV) database. Patients were categorized into three groups based on GPR tertiles: Tertile 1 (n = 1154, range 0.103-1.442), Tertile 2 (n = 1153, range 1.444-1.966), and Tertile 3 (n = 1155, range 1.967-12.937). The primary outcomes studied were 28-day and 90-day all-cause mortality (ACM). To analyze the relationship between GPR and outcomes, we employed Cox regression models adjusted for multiple covariates and restricted cubic splines to explore the potential non-linear association. The 3,462 - patient cohort had a mean age of 67.7 ± 16.6 years, with 58.2% male. The 28-day and 90-day ACM were 21.9% and 31.2%, respectively. Multivariate adjusted analysis showed no overall GPR-ACM correlation at 28 and 90 d. Regarding different groups, with T2 as the reference group (Ref), for 28-day ACM, the adjusted hazard ratio (HR) of the T1 was 1.20 (95% Confidence Interval [CI]: 1.00-1.44, p ≡ P = 0.049), and that of T3 group was 1.22 (95% CI: 1.01-1.47, P = 0.035). For 90 - day ACM, the adjusted HR of the T1 was 1.19 (95% CI: 1.02-1.39, P = 0.023), and the T3 was 1.20 (95% CI: 1.03-1.40). The correlation between the GPR lesvel and ACM was U-shaped association. The left and right - hand side effect sizes at the inflection point (1.65) were 0.472 (HR: 0.472, 95% CI 0.306-0.728, P < 0.001) and 1.127 (HR: 1.127, 95% CI 1.032-1.229, P = 0.0075). Sensitivity analysis was stable. Our findings have revealed a U-shaped relationship between GPR levels and ACM in critically ill patients with TE. Close attention should therefore be paid to this issue in order to improve patient care.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-17T15:36:39.832Z","creation":"2025-08-17T03:06:09.221Z"},"accession":"S-EPMC12287516","cross_references":{"pubmed":["40702256"],"doi":["10.1038/s41598-025-12496-4"]}}