biostudies-literatureZhang Rhe Key Research & Development Program of Hubei ProvinceOpen Fund for the Institute of Gynecological and Obstetric Diseases, Xiangyang Center HospitalHubei Provincial Natural Science Foundation of Chinathe Hubei Provincial Natural Science Foundation Joint Fund Projectthe Keypoint Research and Development Program of Hubei Province26754https://www.ebi.ac.uk/biostudies/studies/S-EPMC12287529biostudies-literatureUnknown15(1)The study investigates the correlation between CD3 T-cell expression levels and cervical cancer (CC) while developing a magnetic resonance (MR) imaging-based radiomics model for preoperative prediction of CD3 T-cell expression levels. Prognostic correlations between CD3D, CD3E, and CD3G gene expressions and various cancers were analyzed using the Cancer Genome Atlas (TCGA) database. Protein-protein interaction (PPI) analysis via the STRING database identified associations between these genes and T lymphocyte activity. Gene Set Enrichment Analysis (GSEA) revealed immune pathway enrichment by categorizing genes based on CD3D expression levels. Correlations between immune checkpoint molecules and CD3 complex genes were also assessed. The study retrospectively included 202 patients with patholScientific reportsPreoperative MRI-based radiomics analysis of intra- and peritumoral regions for predicting CD3 expression in early cervical cancer.PMC122875292025AFD8842023BCB1282023MDI052023AFB1122022BCE019Yang JHuang CAi TLv HLi FXing HQin XJiang CDeng LZhang RLi LWu FfalsePreoperative MRI-based radiomics analysis of intra- and peritumoral regions for predicting CD3 expression in early cervical cancer.The study investigates the correlation between CD3 T-cell expression levels and cervical cancer (CC) while developing a magnetic resonance (MR) imaging-based radiomics model for preoperative prediction of CD3 T-cell expression levels. Prognostic correlations between CD3D, CD3E, and CD3G gene expressions and various cancers were analyzed using the Cancer Genome Atlas (TCGA) database. Protein-protein interaction (PPI) analysis via the STRING database identified associations between these genes and T lymphocyte activity. Gene Set Enrichment Analysis (GSEA) revealed immune pathway enrichment by categorizing genes based on CD3D expression levels. Correlations between immune checkpoint molecules and CD3 complex genes were also assessed. The study retrospectively included 202 patients with pathol2025-01-01T00:00:00Z2025 Jul2026-03-17T15:35:37.988Z2025-08-17T03:06:26.488ZS-EPMC122875294070223610.1038/s41598-025-12162-9