{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cobo Marcos M"],"funding":["Instituto de Salud Carlos III","CIBER CV (Madrid, Spain)"],"pagination":["2460-2466"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12287789"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(4)"],"pubmed_abstract":["<h4>Aims</h4>Early diuresis and natriuresis are commonly used to assess the efficacy of decongestive therapy following an acute heart failure episode. There is limited knowledge regarding which parameter better predicts adverse clinical outcomes, especially in the outpatient setting. This study investigated the prognostic value of both metrics in predicting 30-day adverse clinical events in an ambulatory worsening heart failure (WHF) scenario.<h4>Methods and results</h4>This is a post-hoc analysis of the SALT-HF trial involving 167 patients with ambulatory WHF randomized to receive intravenous furosemide with or without hypertonic saline solution. Early diuretic response was assessed through 3-h urine output and 3-h urinary sodium (uNa<sup>+</sup>) levels following intravenous (IV) diureti"],"journal":["ESC heart failure"],"pubmed_title":["Early diuretic response and outcome prediction in ambulatory worsening heart failure: Natriuresis versus diuresis."],"pmcid":["PMC12287789"],"funding_grant_id":["16/11/00432","16/11/00420","PI20/00689"],"pubmed_authors":["Comin-Colet J","Del Prado Diaz S","Restrepo-Cordoba MA","Nunez J","Zegri-Reiriz I","Rubio Gracia J","Barrios E","Cobo Marcos M","Morales-Rull JL","de Juan Baguda J","Garcia-Pinilla JM","Llacer P","Ortiz Cortes C","Diez-Villanueva P","de la Espriella R","Jimenez-Marrero S"],"additional_accession":[]},"is_claimable":false,"name":"Early diuretic response and outcome prediction in ambulatory worsening heart failure: Natriuresis versus diuresis.","description":"<h4>Aims</h4>Early diuresis and natriuresis are commonly used to assess the efficacy of decongestive therapy following an acute heart failure episode. There is limited knowledge regarding which parameter better predicts adverse clinical outcomes, especially in the outpatient setting. This study investigated the prognostic value of both metrics in predicting 30-day adverse clinical events in an ambulatory worsening heart failure (WHF) scenario.<h4>Methods and results</h4>This is a post-hoc analysis of the SALT-HF trial involving 167 patients with ambulatory WHF randomized to receive intravenous furosemide with or without hypertonic saline solution. Early diuretic response was assessed through 3-h urine output and 3-h urinary sodium (uNa<sup>+</sup>) levels following intravenous (IV) diureti","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-03-17T15:34:28.228Z","creation":"2025-08-17T03:05:54.183Z"},"accession":"S-EPMC12287789","cross_references":{"pubmed":["40152188"],"doi":["10.1002/ehf2.15275"]}}