{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(1)"],"submitter":["Bertone AL"],"pubmed_abstract":["<h4>Background</h4>The use of micro-particulate allografts is rising, but knowledge about the protein characterization and biocompatibility of umbilical cord-derived allografts (UC) in vivo is limited.<h4>Methods</h4>Proteomic analyses using mass spectrometry (MS) determined equine UC protein relative quantification and functions using total spectral counts (TSC). UC cytokines were quantified by enzyme-linked immunosorbent assay (ELISA). Three in vivo studies assessed recipient clinical and tissue biocompatibility in joints and ligaments.<h4>Results</h4>Proteomics revealed 2645 annotated TSCs. Proteins of > 89 TSC were considered abundant and were present in all donors. Proteins within the same donor had a 4.7% mean variation. Inflammatory cytokines were low in UC. In vivo, the prospective"],"journal":["BMC medicine"],"pagination":["439"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12288288"],"repository":["biostudies-literature"],"pubmed_title":["Cryopreserved equine umbilical cord tissue allograft characterization and biocompatibility in vivo in musculoskeletal tissues: a controlled study."],"pmcid":["PMC12288288"],"pubmed_authors":["Ragland D","Bertone AL","Leise B","Reinemeyer C","Tsaprailis G"],"additional_accession":[]},"is_claimable":false,"name":"Cryopreserved equine umbilical cord tissue allograft characterization and biocompatibility in vivo in musculoskeletal tissues: a controlled study.","description":"<h4>Background</h4>The use of micro-particulate allografts is rising, but knowledge about the protein characterization and biocompatibility of umbilical cord-derived allografts (UC) in vivo is limited.<h4>Methods</h4>Proteomic analyses using mass spectrometry (MS) determined equine UC protein relative quantification and functions using total spectral counts (TSC). UC cytokines were quantified by enzyme-linked immunosorbent assay (ELISA). Three in vivo studies assessed recipient clinical and tissue biocompatibility in joints and ligaments.<h4>Results</h4>Proteomics revealed 2645 annotated TSCs. Proteins of > 89 TSC were considered abundant and were present in all donors. Proteins within the same donor had a 4.7% mean variation. Inflammatory cytokines were low in UC. In vivo, the prospective","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-07-15T12:34:23.012Z","creation":"2025-08-28T03:05:57.642Z"},"accession":"S-EPMC12288288","cross_references":{"pubmed":["40702469"],"doi":["10.1186/s12916-025-04231-7"]}}