{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["30(3)"],"submitter":["Zeng LR"],"pubmed_abstract":["Osteosarcoma (OS) is the most frequent type of cancer, as well as a common malignant tumor in orthopedics. Multiple long non-coding RNAs (lncRNAs) are implicated in immune infiltration in numerous types of cancer. Using single-sample gene set enrichment analysis to assign patients with OS, two immunotypes of OS were identified. Using K-means, spectral and PCA-K-means clustering two immunotypes of OS were demonstrated to be reproducible and represent a biologically meaningful classification of patients with OS based on their tumor immune microenvironment. Cluster 1 was an immune-infiltrating type, while Cluster 2 was an immune 'desert' type (low immune cell infiltration). Between Cluster 1 and 2, 29 common differentially expressed lncRNAs (DELs) were identified and univariate Cox regression"],"journal":["Oncology letters"],"pagination":["443"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12288445"],"repository":["biostudies-literature"],"pubmed_title":["Risk score model with two immune infiltration-related long non-coding RNAs to predict prognosis in patients with osteosarcoma."],"pmcid":["PMC12288445"],"pubmed_authors":["Yang G","Zeng LR","Zhu GH","Mei HB"],"additional_accession":[]},"is_claimable":false,"name":"Risk score model with two immune infiltration-related long non-coding RNAs to predict prognosis in patients with osteosarcoma.","description":"Osteosarcoma (OS) is the most frequent type of cancer, as well as a common malignant tumor in orthopedics. Multiple long non-coding RNAs (lncRNAs) are implicated in immune infiltration in numerous types of cancer. Using single-sample gene set enrichment analysis to assign patients with OS, two immunotypes of OS were identified. Using K-means, spectral and PCA-K-means clustering two immunotypes of OS were demonstrated to be reproducible and represent a biologically meaningful classification of patients with OS based on their tumor immune microenvironment. Cluster 1 was an immune-infiltrating type, while Cluster 2 was an immune 'desert' type (low immune cell infiltration). Between Cluster 1 and 2, 29 common differentially expressed lncRNAs (DELs) were identified and univariate Cox regression","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-03-31T10:49:13.558Z","creation":"2025-08-28T03:05:56.302Z"},"accession":"S-EPMC12288445","cross_references":{"pubmed":["40708596"],"doi":["10.3892/ol.2025.15189"]}}