{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["You T"],"funding":["NIDDK"],"pagination":["e193208"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12288974"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(14)"],"pubmed_abstract":["More than 1 in 4 men will undergo surgery for inguinal hernia, which is commonly associated with fibrotic degeneration of the lower abdominal muscle (LAM) in the groin region. Utilizing a male mouse model expressing the human aromatase gene (Aromhum), previous studies showed that locally produced estradiol acting via estrogen receptor α in LAM fibroblasts leads to fibrosis, myofiber atrophy, and hernia development. Here, we found that upregulation of progesterone receptor (PGR) in a LAM fibroblast population mediates this estrogenic effect. A PGR-selective progesterone antagonist in Aromhum mice decreased LAM fibrosis and atrophy, preventing hernia formation and stopping progression of existing hernias. Addition of progesterone to estradiol treatment was essential for early-onset developme"],"journal":["JCI insight"],"pubmed_title":["Role of progesterone action in inguinal hernia formation via skeletal muscle fibrosis and atrophy."],"pmcid":["PMC12288974"],"funding_grant_id":["T32DK007169","R01DK139052","R01DK121529"],"pubmed_authors":["Potluri T","Piehl N","Zandigohar M","You T","Baker E","Dai Y","Lieber RL","Stulberg JJ","Bulun SE","Coon V JS","Kafali M","Escobar DJ","Zhao H"],"additional_accession":[]},"is_claimable":false,"name":"Role of progesterone action in inguinal hernia formation via skeletal muscle fibrosis and atrophy.","description":"More than 1 in 4 men will undergo surgery for inguinal hernia, which is commonly associated with fibrotic degeneration of the lower abdominal muscle (LAM) in the groin region. Utilizing a male mouse model expressing the human aromatase gene (Aromhum), previous studies showed that locally produced estradiol acting via estrogen receptor α in LAM fibroblasts leads to fibrosis, myofiber atrophy, and hernia development. Here, we found that upregulation of progesterone receptor (PGR) in a LAM fibroblast population mediates this estrogenic effect. A PGR-selective progesterone antagonist in Aromhum mice decreased LAM fibrosis and atrophy, preventing hernia formation and stopping progression of existing hernias. Addition of progesterone to estradiol treatment was essential for early-onset developme","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-17T15:36:42.284Z","creation":"2025-08-17T03:06:10.081Z"},"accession":"S-EPMC12288974","cross_references":{"pubmed":["40504614"],"doi":["10.1172/jci.insight.193208"]}}