{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Moisieienko K"],"funding":["Nancy Taylor Foundation","Veterans Affairs National Center for PTSD","NIH HHS"],"pagination":["pyaf040"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12289550"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(7)"],"pubmed_abstract":["Background
Structural and functional brain alterations may be associated with pain and anxiety. We hypothesized that synaptic density (measured in vivo with [11C]UCB-J and positron emission tomography quantification of synaptic vesicle glycoprotein 2A, SV2A) alterations may play a role in higher pain sensitivity and that this relationship may be mediated by anxiety symptoms.Methods
Twenty-one mentally and medically healthy subjects (11 males, 10 females; age 45.1 ± 16.9 years) participated in imaging, acute pain (cold pressor test) and anxiety (State-Trait Anxiety Inventory) assessments. Synaptic vesicle glycoprotein 2A density was quantified as regional volumes of distribution (VT) using a 1-tissue compartment model with a plasma input function. Synaptic vesicle glycoprote"],"journal":["The international journal of neuropsychopharmacology"],"pubmed_title":["Exploring the influence of synaptic density and anxiety on pain perception: evidence from a [11C]UCB-J positron emission tomography imaging study."],"pmcid":["PMC12289550"],"funding_grant_id":["KL2-TR001862","R01-MH104459"],"pubmed_authors":["Davis MT","Pietrzak RH","Moisieienko K","Asch RH","Esterlis I"],"additional_accession":[]},"is_claimable":false,"name":"Exploring the influence of synaptic density and anxiety on pain perception: evidence from a [11C]UCB-J positron emission tomography imaging study.","description":"Background
Structural and functional brain alterations may be associated with pain and anxiety. We hypothesized that synaptic density (measured in vivo with [11C]UCB-J and positron emission tomography quantification of synaptic vesicle glycoprotein 2A, SV2A) alterations may play a role in higher pain sensitivity and that this relationship may be mediated by anxiety symptoms.Methods
Twenty-one mentally and medically healthy subjects (11 males, 10 females; age 45.1 ± 16.9 years) participated in imaging, acute pain (cold pressor test) and anxiety (State-Trait Anxiety Inventory) assessments. Synaptic vesicle glycoprotein 2A density was quantified as regional volumes of distribution (VT) using a 1-tissue compartment model with a plasma input function. Synaptic vesicle glycoprote","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-31T11:11:31.042Z","creation":"2025-08-28T03:09:15.329Z"},"accession":"S-EPMC12289550","cross_references":{"pubmed":["40511849"],"doi":["10.1093/ijnp/pyaf040"]}}