biostudies-literatureMoisieienko KNancy Taylor FoundationVeterans Affairs National Center for PTSDNIH HHSpyaf040https://www.ebi.ac.uk/biostudies/studies/S-EPMC12289550biostudies-literatureUnknown28(7)<h4>Background</h4>Structural and functional brain alterations may be associated with pain and anxiety. We hypothesized that synaptic density (measured in vivo with [11C]UCB-J and positron emission tomography quantification of synaptic vesicle glycoprotein 2A, SV2A) alterations may play a role in higher pain sensitivity and that this relationship may be mediated by anxiety symptoms.<h4>Methods</h4>Twenty-one mentally and medically healthy subjects (11 males, 10 females; age 45.1 ± 16.9 years) participated in imaging, acute pain (cold pressor test) and anxiety (State-Trait Anxiety Inventory) assessments. Synaptic vesicle glycoprotein 2A density was quantified as regional volumes of distribution (VT) using a 1-tissue compartment model with a plasma input function. Synaptic vesicle glycoproteThe international journal of neuropsychopharmacologyExploring the influence of synaptic density and anxiety on pain perception: evidence from a [11C]UCB-J positron emission tomography imaging study.PMC12289550KL2-TR001862R01-MH104459Davis MTPietrzak RHMoisieienko KAsch RHEsterlis IfalseExploring the influence of synaptic density and anxiety on pain perception: evidence from a [11C]UCB-J positron emission tomography imaging study.<h4>Background</h4>Structural and functional brain alterations may be associated with pain and anxiety. We hypothesized that synaptic density (measured in vivo with [11C]UCB-J and positron emission tomography quantification of synaptic vesicle glycoprotein 2A, SV2A) alterations may play a role in higher pain sensitivity and that this relationship may be mediated by anxiety symptoms.<h4>Methods</h4>Twenty-one mentally and medically healthy subjects (11 males, 10 females; age 45.1 ± 16.9 years) participated in imaging, acute pain (cold pressor test) and anxiety (State-Trait Anxiety Inventory) assessments. Synaptic vesicle glycoprotein 2A density was quantified as regional volumes of distribution (VT) using a 1-tissue compartment model with a plasma input function. Synaptic vesicle glycoprote2025-01-01T00:00:00Z2025 Jul2026-03-31T11:11:31.042Z2025-08-28T03:09:15.329ZS-EPMC122895504051184910.1093/ijnp/pyaf040