{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mooney C"],"funding":["Science Foundation Ireland","Brain and Behavior Research Foundation","University of Trento"],"pagination":["10614-10634"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12289737"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["62(8)"],"pubmed_abstract":["Autism spectrum disorder (ASD) is a neurodevelopmental condition caused by both genetic and environmental factors. Since no single gene variant accounts for more than 1% of the cases, the converging actions of ASD-related genes and other factors, including microRNAs (miRNAs), may contribute to ASD pathogenesis. To date, few studies have simultaneously investigated the mRNA and miRNA profiles in an ASD-relevant model. The BTBR mouse strain displays a range of behaviors with ASD-like features but little is known about the protein-coding and noncoding gene expression landscape that may underlie the ASD-like phenotype. Here we performed parallel mRNA and miRNA profiling using the prefrontal cortex (PFC) of BTBR and C57BL/6 J (B6) mice. This identified 1063 differentially expressed genes and 48"],"journal":["Molecular neurobiology"],"pubmed_title":["Deregulated mRNA and microRNA Expression Patterns in the Prefrontal Cortex of the BTBR Mouse Model of Autism."],"pmcid":["PMC12289737"],"funding_grant_id":["NARSAD Young Investigator Grant, ID: 26617","Starting Grant for Young Researchers 2019","16/RC/3948 and 21/RC/10294_P2, FutureNeuro"],"pubmed_authors":["Grigoli A","Ricceri L","Jimenez-Mateos EM","Clementi E","Parlante A","Scattoni ML","Henshall DC","Canarutto G","Mooney C","Sanz-Rodriguez A","Provenzano G","Piazza S"],"additional_accession":[]},"is_claimable":false,"name":"Deregulated mRNA and microRNA Expression Patterns in the Prefrontal Cortex of the BTBR Mouse Model of Autism.","description":"Autism spectrum disorder (ASD) is a neurodevelopmental condition caused by both genetic and environmental factors. Since no single gene variant accounts for more than 1% of the cases, the converging actions of ASD-related genes and other factors, including microRNAs (miRNAs), may contribute to ASD pathogenesis. To date, few studies have simultaneously investigated the mRNA and miRNA profiles in an ASD-relevant model. The BTBR mouse strain displays a range of behaviors with ASD-like features but little is known about the protein-coding and noncoding gene expression landscape that may underlie the ASD-like phenotype. Here we performed parallel mRNA and miRNA profiling using the prefrontal cortex (PFC) of BTBR and C57BL/6 J (B6) mice. This identified 1063 differentially expressed genes and 48","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-03-15T16:38:04.964Z","creation":"2025-08-13T03:04:31.98Z"},"accession":"S-EPMC12289737","cross_references":{"pubmed":["40227316"],"doi":["10.1007/s12035-025-04900-x"]}}