{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tian Y"],"funding":["Key Discipline Construction Project of Shanghai Pudong New Area Health Commission","Small and Micro Science and Technology Project of National Health Commission"],"pagination":["751"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12289799"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["52(1)"],"pubmed_abstract":["<h4>Background</h4>Nephrotoxicity is a common adverse effect of many chemotherapeutic agents and represents a major dose-limiting factor in cancer treatment. Therefore, developing effective renoprotective strategies is urgently needed. Molecular hydrogen (H<sub>2</sub>) has emerged as a therapeutic agent with potent antioxidant and anti-inflammatory properties, selectively scavenging hydroxyl radicals and alleviating tissue injury. However, the protective effects and underlying mechanisms of H<sub>2</sub> in chemotherapy-induced acute kidney injury (AKI) remain poorly understood.<h4>Methods</h4>A cisplatin-induced AKI mouse model was established with or without H₂ administration. Kidney injury biomarkers were evaluated, and levels of inflammation and apoptosis were assessed using TUNEL sta"],"journal":["Molecular biology reports"],"pubmed_title":["Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism."],"pmcid":["PMC12289799"],"funding_grant_id":["20004","PWZxk2022-20"],"pubmed_authors":["Fan W","Geng X","Zhang Y","Tian Y","Chen Y","Wang Y","Tang W","Su H","Wei Y","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism.","description":"<h4>Background</h4>Nephrotoxicity is a common adverse effect of many chemotherapeutic agents and represents a major dose-limiting factor in cancer treatment. Therefore, developing effective renoprotective strategies is urgently needed. Molecular hydrogen (H<sub>2</sub>) has emerged as a therapeutic agent with potent antioxidant and anti-inflammatory properties, selectively scavenging hydroxyl radicals and alleviating tissue injury. However, the protective effects and underlying mechanisms of H<sub>2</sub> in chemotherapy-induced acute kidney injury (AKI) remain poorly understood.<h4>Methods</h4>A cisplatin-induced AKI mouse model was established with or without H₂ administration. Kidney injury biomarkers were evaluated, and levels of inflammation and apoptosis were assessed using TUNEL sta","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-15T16:16:44.347Z","creation":"2025-08-13T03:04:42.539Z"},"accession":"S-EPMC12289799","cross_references":{"pubmed":["40705191"],"doi":["10.1007/s11033-025-10845-0"]}}