biostudies-literatureTian YKey Discipline Construction Project of Shanghai Pudong New Area Health CommissionSmall and Micro Science and Technology Project of National Health Commission751https://www.ebi.ac.uk/biostudies/studies/S-EPMC12289799biostudies-literatureUnknown52(1)<h4>Background</h4>Nephrotoxicity is a common adverse effect of many chemotherapeutic agents and represents a major dose-limiting factor in cancer treatment. Therefore, developing effective renoprotective strategies is urgently needed. Molecular hydrogen (H₂) has emerged as a therapeutic agent with potent antioxidant and anti-inflammatory properties, selectively scavenging hydroxyl radicals and alleviating tissue injury. However, the protective effects and underlying mechanisms of H₂ in chemotherapy-induced acute kidney injury (AKI) remain poorly understood.<h4>Methods</h4>A cisplatin-induced AKI mouse model was established with or without H₂ administration. Kidney injury biomarkers were evaluated, and levels of inflammation and apoptosis were assessed using TUNEL staMolecular biology reportsMolecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism.PMC1228979920004PWZxk2022-20Fan WGeng XZhang YTian YChen YWang YTang WSu HWei YZhou JfalseMolecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism.<h4>Background</h4>Nephrotoxicity is a common adverse effect of many chemotherapeutic agents and represents a major dose-limiting factor in cancer treatment. Therefore, developing effective renoprotective strategies is urgently needed. Molecular hydrogen (H₂) has emerged as a therapeutic agent with potent antioxidant and anti-inflammatory properties, selectively scavenging hydroxyl radicals and alleviating tissue injury. However, the protective effects and underlying mechanisms of H₂ in chemotherapy-induced acute kidney injury (AKI) remain poorly understood.<h4>Methods</h4>A cisplatin-induced AKI mouse model was established with or without H₂ administration. Kidney injury biomarkers were evaluated, and levels of inflammation and apoptosis were assessed using TUNEL sta2025-01-01T00:00:00Z2025 Jul2026-03-15T16:16:44.347Z2025-08-13T03:04:42.539ZS-EPMC122897994070519110.1007/s11033-025-10845-0