biostudies-literatureUnknown73(8)Kayawake H<h4>Objectives</h4>Generally, HLA matching between donors and recipients is not performed in lung transplantation (LTx). Therefore, whether HLA mismatch between donors and recipients (D/R mismatch) influences postoperative outcomes after LTx remains uncertain. In this study, we investigated the influence of D/R mismatch on postoperative outcomes after cadaveric LTx (CLT).<h4>Methods</h4>A total of 140 CLT procedures were performed between 2012 and 2020. After excluding 5 recipients with preformed DSA and 1 recipient undergoing re-LTx, 134 recipients were enrolled in this retrospective study. The postoperative outcomes were compared between recipients with higher and lower D/R mismatches.<h4>Results</h4>The median D/R mismatch (A/B/DR loci) was 4.0 (range, 1-6). When dividing these 134 reciGeneral thoracic and cardiovascular surgery609-615https://www.ebi.ac.uk/biostudies/studies/S-EPMC12289801biostudies-literatureInfluence of HLA mismatch between donors and recipients on postoperative outcomes in cadaveric lung transplantation.PMC12289801Ryo TDate HSakanoue IMatsumoto AMatsubara TTanaka SYutaka YNakajima DNishino YKayawake HfalseInfluence of HLA mismatch between donors and recipients on postoperative outcomes in cadaveric lung transplantation.<h4>Objectives</h4>Generally, HLA matching between donors and recipients is not performed in lung transplantation (LTx). Therefore, whether HLA mismatch between donors and recipients (D/R mismatch) influences postoperative outcomes after LTx remains uncertain. In this study, we investigated the influence of D/R mismatch on postoperative outcomes after cadaveric LTx (CLT).<h4>Methods</h4>A total of 140 CLT procedures were performed between 2012 and 2020. After excluding 5 recipients with preformed DSA and 1 recipient undergoing re-LTx, 134 recipients were enrolled in this retrospective study. The postoperative outcomes were compared between recipients with higher and lower D/R mismatches.<h4>Results</h4>The median D/R mismatch (A/B/DR loci) was 4.0 (range, 1-6). When dividing these 134 reci2025-01-01T00:00:00Z2025 Aug2026-03-27T17:07:19.144Z2025-08-28T03:09:21.585ZS-EPMC122898013965230410.1007/s11748-024-02109-8