biostudies-literatureLiu JNational Natural Science Foundation of China (National Science Foundation of China)56https://www.ebi.ac.uk/biostudies/studies/S-EPMC12289874biostudies-literatureUnknown17(1)Periodontal bone defects, primarily caused by periodontitis, are highly prevalent in clinical settings and manifest as bone fenestration, dehiscence, or attachment loss, presenting a significant challenge to oral health. In regenerative medicine, harnessing developmental principles for tissue repair offers promising therapeutic potential. Of particular interest is the condensation of progenitor cells, an essential event in organogenesis that has inspired clinically effective cell aggregation approaches in dental regeneration. However, the precise cellular coordination mechanisms during condensation and regeneration remain elusive. Here, taking the tooth as a model organ, we employed single-cell RNA sequencing to dissect the cellular composition and heterogeneity of human dental follicle anInternational journal of oral scienceSingle-cell transcriptomics identifies PDGFRA<sup>+</sup> progenitors orchestrating angiogenesis and periodontal tissue regeneration.PMC122898748237102082401201819300258217098882471011Tian JSui BLiu JLiu LHe JChen JLiu PZhang NWang HXu HJin YJin FBai SMa CZhang ZLei XZhang YCao YZhang XGao YZheng CLuo XCai XfalseSingle-cell transcriptomics identifies PDGFRA<sup>+</sup> progenitors orchestrating angiogenesis and periodontal tissue regeneration.Periodontal bone defects, primarily caused by periodontitis, are highly prevalent in clinical settings and manifest as bone fenestration, dehiscence, or attachment loss, presenting a significant challenge to oral health. In regenerative medicine, harnessing developmental principles for tissue repair offers promising therapeutic potential. Of particular interest is the condensation of progenitor cells, an essential event in organogenesis that has inspired clinically effective cell aggregation approaches in dental regeneration. However, the precise cellular coordination mechanisms during condensation and regeneration remain elusive. Here, taking the tooth as a model organ, we employed single-cell RNA sequencing to dissect the cellular composition and heterogeneity of human dental follicle an2025-01-01T00:00:00Z2025 Jul2026-03-31T11:12:15.408Z2025-08-28T03:09:16.392ZS-EPMC122898744070744710.1038/s41368-025-00384-6