{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sullivan SA"],"funding":["Chang Gung Memorial Hospital, Linkou (Linkou Chang Gung Memorial Hospital)","U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)"],"pagination":["6487"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12289875"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Trichomonas vaginalis, the causative agent of the venereal disease trichomoniasis, infects men and women globally and is associated with serious outcomes during pregnancy, increased risk of HIV-1 infection, and cancers of the human reproductive tract. Species of trichomonad parasitize a range of hosts in addition to humans, including birds, livestock, and pets. Genetic analysis of trichomonads recovered from columbid birds has provided evidence that they undergo frequent host-switching, and that a spillover event from columbids likely gave rise to T. vaginalis in humans. Here we describe a comparative genomics study of seven trichomonad species, generating chromosome-scale reference genomes for T. vaginalis and its avian sister species Trichomonas stableri, and assemblies of five other spe"],"journal":["Nature communications"],"pubmed_title":["Comparative genomics of the parasite Trichomonas vaginalis reveals genes involved in spillover from birds to humans."],"pmcid":["PMC12289875"],"funding_grant_id":["R21AI149449","CMRPD1M0571-2","U24AI183870"],"pubmed_authors":["Liu H","Chandler C","Peters A","Chiu CH","Rogers KH","Srivastava H","Lee H","Schatz MC","Chen TW","Callejas-Hernandez F","Raidal SR","Liachko I","Tang P","Berenberg D","Mangelson H","Yeh YM","Carlton JM","Ranallo-Benavidez TR","Girard YA","Bonneau RA","Sullivan SA","Lee CC","Johnson CK","Gerhold R","Huang PJ","Orosco JC","Blow F"],"additional_accession":[]},"is_claimable":false,"name":"Comparative genomics of the parasite Trichomonas vaginalis reveals genes involved in spillover from birds to humans.","description":"Trichomonas vaginalis, the causative agent of the venereal disease trichomoniasis, infects men and women globally and is associated with serious outcomes during pregnancy, increased risk of HIV-1 infection, and cancers of the human reproductive tract. Species of trichomonad parasitize a range of hosts in addition to humans, including birds, livestock, and pets. Genetic analysis of trichomonads recovered from columbid birds has provided evidence that they undergo frequent host-switching, and that a spillover event from columbids likely gave rise to T. vaginalis in humans. Here we describe a comparative genomics study of seven trichomonad species, generating chromosome-scale reference genomes for T. vaginalis and its avian sister species Trichomonas stableri, and assemblies of five other spe","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-03-15T16:59:34.72Z","creation":"2025-08-13T03:04:33.665Z"},"accession":"S-EPMC12289875","cross_references":{"pubmed":["40707449"],"doi":["10.1038/s41467-025-61483-w"]}}