biostudies-literatureLee KHRural Development Administration's Regional Specialized Crop Technology Development Project30467-30488https://www.ebi.ac.uk/biostudies/studies/S-EPMC12290619biostudies-literatureUnknown10(28)Age-related macular degeneration (AMD) is a progressive, late-onset, genetic (CFH, HTRA), and environmental (smoking, aging) ocular disease that is a leading cause of blindness affecting more than 200 million people worldwide. New treatments are required for fibrosis, autophagy, and microglia-driven pathologies in AMD patients for personalized medicine approaches, considering that only 10% of AMD patients are treated using the current medicine. The current study examined ninety-one compounds using a phenotypic drug discovery platform in vitro and in vivo to find potential drug candidates that include a new chemical entity (NCE) and extracts from plants such as , , and . The phenotypic drug discovery platform determined mitochondrial function quantitatively by measuring the oxACS omegaPhenotypic Drug Discovery Platform by Quantitative High-Throughput Screening Identifies Antiapoptotic Molecules in a Zebrafish Model of Age-Related Macular Degeneration.PMC12290619PJ01696801Jahng WJStewart JMJung JJeong EHChoo DWSeong HWAhn GHKim JSRyu JMPark BYoo GSKim YSSamadi AFJee DHLee KHJin LfalsePhenotypic Drug Discovery Platform by Quantitative High-Throughput Screening Identifies Antiapoptotic Molecules in a Zebrafish Model of Age-Related Macular Degeneration.Age-related macular degeneration (AMD) is a progressive, late-onset, genetic (CFH, HTRA), and environmental (smoking, aging) ocular disease that is a leading cause of blindness affecting more than 200 million people worldwide. New treatments are required for fibrosis, autophagy, and microglia-driven pathologies in AMD patients for personalized medicine approaches, considering that only 10% of AMD patients are treated using the current medicine. The current study examined ninety-one compounds using a phenotypic drug discovery platform in vitro and in vivo to find potential drug candidates that include a new chemical entity (NCE) and extracts from plants such as , , and . The phenotypic drug discovery platform determined mitochondrial function quantitatively by measuring the ox2025-01-01T00:00:00Z2025 Jul2026-05-09T17:53:58.279Z2026-04-08T01:08:01.875ZS-EPMC122906194072780110.1021/acsomega.5c02227