{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pires Costa E"],"funding":["Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","Funda??o de Amparo ? Pesquisa do Estado de Minas Gerais","Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior"],"pagination":["31033-31045"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12290672"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(28)"],"pubmed_abstract":["Different therapeutic approaches, particularly those involving plant-derived compounds, have been explored for treating inflammatory diseases. This study evaluated the antioxidant and anti-inflammatory properties of eugenol (EU) in its pure form, bis-eugenol (BIS), and clove essential oil (OE) at different concentrations (5, 10, and 25 μg/mL). Chemical analysis confirmed that OE contains a high proportion of eugenol (45-90%), with the presence of eugenol acetate differentiating it from pure eugenol, while bis-eugenol was successfully synthesized and characterized with a 97% yield. Antioxidant activity assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays showed that 25 μg/mL of each compound effectively neutralized free radicals and reduced fe"],"journal":["ACS omega"],"pubmed_title":["Antioxidant and Anti-inflammatory Activity of Eugenol, Bis-eugenol, and Clove Essential Oil: An In Vitro Study."],"pmcid":["PMC12290672"],"funding_grant_id":["001","310413/2023-0","403194/2023-7","APQ-03519-22","306733/2023-4","APQ-04164-22"],"pubmed_authors":["Maciel Dos Santos M","da Silva DA","Teixeira RR","de Paula RA","Pires Costa E","Lopes RP","Goncalves RV"],"additional_accession":[]},"is_claimable":false,"name":"Antioxidant and Anti-inflammatory Activity of Eugenol, Bis-eugenol, and Clove Essential Oil: An In Vitro Study.","description":"Different therapeutic approaches, particularly those involving plant-derived compounds, have been explored for treating inflammatory diseases. This study evaluated the antioxidant and anti-inflammatory properties of eugenol (EU) in its pure form, bis-eugenol (BIS), and clove essential oil (OE) at different concentrations (5, 10, and 25 μg/mL). Chemical analysis confirmed that OE contains a high proportion of eugenol (45-90%), with the presence of eugenol acetate differentiating it from pure eugenol, while bis-eugenol was successfully synthesized and characterized with a 97% yield. Antioxidant activity assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays showed that 25 μg/mL of each compound effectively neutralized free radicals and reduced fe","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-05-09T19:10:20.413Z","creation":"2026-04-08T01:10:42.61Z"},"accession":"S-EPMC12290672","cross_references":{"pubmed":["40727828"],"doi":["10.1021/acsomega.5c04146"]}}