{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(28)"],"submitter":["Zheng M"],"pubmed_abstract":["The detection of is crucial for the diagnosis and treatment of infectious diseases. However, developing a simple and sensitive method for detection remains challenging. Herein, we propose a sensitive surface-enhanced Raman spectroscopy (SERS) platform for the detection of using core-shell aptamer-Au@Fe<sub>3</sub>O<sub>4</sub> nanoparticles (Fe<sub>3</sub>O<sub>4</sub>-Au@apt) and freezing SERS tags. Core-shell Au@Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticles were modified with specific primary aptamers for precise and efficient capture of , followed by modification with large amounts of secondary aptamers and tetramercaptobenzoic acid through freezing. The proposed SERS platform demonstrated significant sensitivity toward , with a limit of detection of 6.91 CFU/mL, which demonstrates 99.25 times higher sensitivity than conventional SERS tags. Additionally, the proposed SERS platform achieved good recovery rates in human urine and serum samples, ranging from 97.7% to 104.0% and 90.5% to 104.7%. The findings of the study suggest that the proposed SERS platform holds promise for the rapid and efficient detection of pathogenic bacteria."],"journal":["ACS omega"],"pagination":["30651-30659"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12290702"],"repository":["biostudies-literature"],"pubmed_title":["Sensitive SERS Platform for the Detection of via Freezing SERS Tags and Core-Shell Aptamer-Au@Fe&lt;sub&gt;3&lt;/sub&gt;O&lt;sub&gt;4&lt;/sub&gt; Nanoparticles."],"pmcid":["PMC12290702"],"pubmed_authors":["Zhang W","Sun L","Wang Q","Zhu J","Zheng M","Xiao Y","Chen L","Lv S","Lin H","Luo S"],"additional_accession":[]},"is_claimable":false,"name":"Sensitive SERS Platform for the Detection of via Freezing SERS Tags and Core-Shell Aptamer-Au@Fe&lt;sub&gt;3&lt;/sub&gt;O&lt;sub&gt;4&lt;/sub&gt; Nanoparticles.","description":"The detection of is crucial for the diagnosis and treatment of infectious diseases. However, developing a simple and sensitive method for detection remains challenging. Herein, we propose a sensitive surface-enhanced Raman spectroscopy (SERS) platform for the detection of using core-shell aptamer-Au@Fe<sub>3</sub>O<sub>4</sub> nanoparticles (Fe<sub>3</sub>O<sub>4</sub>-Au@apt) and freezing SERS tags. Core-shell Au@Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticles were modified with specific primary aptamers for precise and efficient capture of , followed by modification with large amounts of secondary aptamers and tetramercaptobenzoic acid through freezing. The proposed SERS platform demonstrated significant sensitivity toward , with a limit of detection of 6.91 CFU/mL, which demonstrates 99.25 times higher sensitivity than conventional SERS tags. Additionally, the proposed SERS platform achieved good recovery rates in human urine and serum samples, ranging from 97.7% to 104.0% and 90.5% to 104.7%. The findings of the study suggest that the proposed SERS platform holds promise for the rapid and efficient detection of pathogenic bacteria.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-05-09T17:54:22.919Z","creation":"2026-04-08T01:08:22.322Z"},"accession":"S-EPMC12290702","cross_references":{"pubmed":["40727747"],"doi":["10.1021/acsomega.5c02638"]}}