biostudies-literatureUnknown8(7)Turchin A<h4>Importance</h4>Sulfonylureas are commonly used to treat type 2 diabetes (T2D). Research findings on cardiovascular risk associated with sulfonylureas have been inconsistent.<h4>Objective</h4>To emulate a target trial that compares the risk of cardiovascular events after initiation of treatment with individual sulfonylureas or dipeptidyl peptidase 4 inhibitors (DPP4is).<h4>Design, setting, and participants</h4>This comparative effectiveness research study included individuals with T2D and moderate cardiovascular risk treated with metformin monotherapy who received care at 1 of 10 US health systems or were insured by 1 of 2 large health insurance plans between January 1, 2014, and January 1, 2023. Data were analyzed from July 2024 to March 2025.<h4>Exposure</h4>Initiation of treatment wiJAMA network opene2523067https://www.ebi.ac.uk/biostudies/studies/S-EPMC12290728biostudies-literatureCardiovascular Events in Individuals Treated With Sulfonylureas or Dipeptidyl Peptidase 4 Inhibitors.PMC12290728DeVries ATurchin AKaul AFHegermiller ECarnahan RMcDonnell MENair VGoel SPriest EHernan MALansang MCPetito LCWilley VJfalseCardiovascular Events in Individuals Treated With Sulfonylureas or Dipeptidyl Peptidase 4 Inhibitors.<h4>Importance</h4>Sulfonylureas are commonly used to treat type 2 diabetes (T2D). Research findings on cardiovascular risk associated with sulfonylureas have been inconsistent.<h4>Objective</h4>To emulate a target trial that compares the risk of cardiovascular events after initiation of treatment with individual sulfonylureas or dipeptidyl peptidase 4 inhibitors (DPP4is).<h4>Design, setting, and participants</h4>This comparative effectiveness research study included individuals with T2D and moderate cardiovascular risk treated with metformin monotherapy who received care at 1 of 10 US health systems or were insured by 1 of 2 large health insurance plans between January 1, 2014, and January 1, 2023. Data were analyzed from July 2024 to March 2025.<h4>Exposure</h4>Initiation of treatment wi2025-01-01T00:00:00Z2025 Jul2026-03-27T17:03:31.422Z2025-08-28T03:08:48.436ZS-EPMC122907284070532910.1001/jamanetworkopen.2025.23067