biostudies-literatureUnknown8(7)Woodworth MH<h4>Importance</h4>Intestinal multidrug-resistant organism (MDRO) colonization is highly prevalent in long-term acute care hospital (LTACH) patients and is associated with MDRO infection and transmission. However, there are no therapies approved by the US Food and Drug Administration to reduce intestinal MDRO colonization.<h4>Objective</h4>To determine the safety and acceptability of fecal microbiota transplantation (FMT) in LTACH patients.<h4>Design, setting, and participants</h4>This single-center, open-label nonrandomized clinical trial was conducted from April to December 2023 at an LTACH in the Southeastern US with median 50-patient census and 28-day length of stay. Patients with MDRO colonization were identified by perirectal prevalence sampling. Patients colonized with at least 1 taJAMA network opene2522740https://www.ebi.ac.uk/biostudies/studies/S-EPMC12290730biostudies-literatureMicrobiota Transplantation Among Patients Receiving Long-Term Care: The Sentinel REACT Nonrandomized Clinical Trial.PMC12290730Acharya ASuchindran DRSpalding Walters MHalpin ALVan Riel JLohsen SFridkin SKBower CWBabiker ATrehan TWoodworth MHGrooms LRoghmann MCSteed DBSamore MHMehta CCBurd EMHayden MKAshley AReddy SCSatola SWPrakash-Asrani RKoundakjian DfalseMicrobiota Transplantation Among Patients Receiving Long-Term Care: The Sentinel REACT Nonrandomized Clinical Trial.<h4>Importance</h4>Intestinal multidrug-resistant organism (MDRO) colonization is highly prevalent in long-term acute care hospital (LTACH) patients and is associated with MDRO infection and transmission. However, there are no therapies approved by the US Food and Drug Administration to reduce intestinal MDRO colonization.<h4>Objective</h4>To determine the safety and acceptability of fecal microbiota transplantation (FMT) in LTACH patients.<h4>Design, setting, and participants</h4>This single-center, open-label nonrandomized clinical trial was conducted from April to December 2023 at an LTACH in the Southeastern US with median 50-patient census and 28-day length of stay. Patients with MDRO colonization were identified by perirectal prevalence sampling. Patients colonized with at least 1 ta2025-01-01T00:00:00Z2025 Jul2026-03-31T11:11:31.932Z2025-08-28T03:09:18.823ZS-EPMC122907304070533310.1001/jamanetworkopen.2025.22740