{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Mello LLO"],"funding":["Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","Funda??o de Amparo ? Pesquisa do Estado de Minas Gerais","Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior"],"pagination":["30773-30784"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12290960"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(28)"],"pubmed_abstract":["Schistosomiasis, a neglected tropical disease (NTD) caused by flatworms of the genus <i>Schistosoma</i>, affects more than 250 million people globally. Praziquantel (PZQ) remains the sole therapeutic option, underscoring the need for novel treatments. This study investigates the antischistosomal activity of <i>Eremanthus erythropappus</i> DC. MacLeish (Asteraceae) extracts, and their isolated compounds are against <i>Schistosoma mansoni</i>. <i>In vitro</i> assays revealed that the rinsed extract (LEE) exhibited a significantly lower EC<sub>50</sub> (18.1 μg/mL) compared to that of the ethanolic extract (EEE) (191.5 μg/mL), with no cytotoxicity observed at concentrations up to 500 μg/mL. UHPLC-ESI-MS/MS analysis annotated 16 metabolites, including sesquiterpene lactones (STLs) and pentacyc"],"journal":["ACS omega"],"pubmed_title":["&lt;i&gt;Eremanthus erythropappus&lt;/i&gt; as a Source of Antiparasitic Agents: &lt;i&gt;In Vitro&lt;/i&gt; and &lt;i&gt;In Vivo&lt;/i&gt; Efficacy against &lt;i&gt;Schistosoma mansoni&lt;/i&gt;."],"pmcid":["PMC12290960"],"funding_grant_id":["001","00x0ma614","APQ-03773-22","APQ-00705-22","2023/08418-6"],"pubmed_authors":["de Moraes J","de Mello LLO","Amaro MC","Amarante GW","Andrade-de-Siqueira AI","da Silva Filho AA","Leal CM"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;Eremanthus erythropappus&lt;/i&gt; as a Source of Antiparasitic Agents: &lt;i&gt;In Vitro&lt;/i&gt; and &lt;i&gt;In Vivo&lt;/i&gt; Efficacy against &lt;i&gt;Schistosoma mansoni&lt;/i&gt;.","description":"Schistosomiasis, a neglected tropical disease (NTD) caused by flatworms of the genus <i>Schistosoma</i>, affects more than 250 million people globally. Praziquantel (PZQ) remains the sole therapeutic option, underscoring the need for novel treatments. This study investigates the antischistosomal activity of <i>Eremanthus erythropappus</i> DC. MacLeish (Asteraceae) extracts, and their isolated compounds are against <i>Schistosoma mansoni</i>. <i>In vitro</i> assays revealed that the rinsed extract (LEE) exhibited a significantly lower EC<sub>50</sub> (18.1 μg/mL) compared to that of the ethanolic extract (EEE) (191.5 μg/mL), with no cytotoxicity observed at concentrations up to 500 μg/mL. UHPLC-ESI-MS/MS analysis annotated 16 metabolites, including sesquiterpene lactones (STLs) and pentacyc","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-05-09T19:10:21.657Z","creation":"2026-04-08T01:10:43.147Z"},"accession":"S-EPMC12290960","cross_references":{"pubmed":["40727752"],"doi":["10.1021/acsomega.5c03005"]}}